Document Detail

The clinical significance of EEG cyclic alternating pattern during coma.
MedLine Citation:
PMID:  18090521     Owner:  NLM     Status:  MEDLINE    
To define the clinical significance of EEG "cyclic alternating pattern" (ECAP). ECAP is the periodic presence of a high-voltage slow waves alternating with low voltage irregular faster activity. This term was first described in comatose patients in 1944. It has been less recognized and may be underreported since then. The clinical significance of ECAP in the state of coma remains unknown. We reviewed our prospective EEG database for consecutive patients studied over a period of 4 years (n = 4,819) looking for patterns consistent with ECAP. We reviewed the charts of the patients with the above EEG pattern to define the clinical setting and the eventual outcome. Eleven patients were identified. All patients identified were found to be in the coma state at the time of the EEG. The majority of patients (n = 10) survived the coma, and half returned to the community in good functional status. ECAP is seen rarely in comatose patients. Regardless of the cause of the coma, the presence of ECAP carries an overall good prognosis for both survival and recovery.
Mounzer Y Kassab; Muhammad U Farooq; Ramon Diaz-Arrastia; Paul C Van Ness
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society     Volume:  24     ISSN:  0736-0258     ISO Abbreviation:  J Clin Neurophysiol     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-19     Completed Date:  2008-01-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506708     Medline TA:  J Clin Neurophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  425-8     Citation Subset:  IM    
Department of Neurology and Ophthalmology, Michigan State University, East Lansing, MI 48824, USA.
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MeSH Terms
Activities of Daily Living
Coma / diagnosis*,  drug therapy,  etiology,  mortality,  physiopathology
Follow-Up Studies
Middle Aged
Prospective Studies
Psychotropic Drugs / therapeutic use
Recovery of Function
Rehabilitation Centers
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Psychotropic Drugs

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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