| A clinical role for [(123)I]MIBG myocardial scintigraphy in the distinction between dementia of the Alzheimer's-type and dementia with Lewy bodies. | |
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MedLine Citation:
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PMID: 11606666 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Scintigraphy with [(123)I]metaiodobenzyl guanidine ([(123)I]MIBG) enables the quantification of postganglionic sympathetic cardiac innervation. Recently, myocardial [(123)I]MIBG scintigraphy has been found to be useful in distinguishing Parkinson's disease, a Lewy body disease, from other akinetic rigid syndromes. Some patients initially diagnosed with dementia of the Alzheimer's type (DAT) are discovered to have an alternative disease such as dementia with Lewy bodies (DLB), despite the application of stringent diagnostic criteria. In the present study, examinations were performed to clarify the usefulness of myocardial [(123)I]MIBG scintigraphy in improving the differential diagnosis between patients with DLB and DAT. METHODS: Fourteen patients with DLB and 14 patients with DAT underwent scintigraphy with [(123)I]MIBG, combined with orthostatic tests and cardiac examinations. RESULTS: In all patients with DLB, the heart to mediastinum (H/M) ratio of MIBG uptake was pathologically impaired in both early and delayed images, independently of the duration of disease and autonomic failure. All patients with DAT had successful MIBG uptake in the heart regardless of duration of disease and autonomic failure. Orthostatic hypotension was seen in four patients with DAT and 13 patients with DLB. CONCLUSIONS: [(123)I]MIBG myocardial scintigraphy might detect early disturbances of the sympathetic nervous system in DLB and might provide useful diagnostic information to discriminate DLB from DAT. The distinction between DLB and DAT may be improved by greater emphasis on cardiac sympathetic disturbances. |
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Authors:
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M Yoshita; J Taki; M Yamada |
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Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Journal of neurology, neurosurgery, and psychiatry Volume: 71 ISSN: 0022-3050 ISO Abbreviation: J. Neurol. Neurosurg. Psychiatr. Publication Date: 2001 Nov |
Date Detail:
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Created Date: 2001-10-18 Completed Date: 2001-12-07 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 2985191R Medline TA: J Neurol Neurosurg Psychiatry Country: England |
Other Details:
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Languages: eng Pagination: 583-8 Citation Subset: IM |
Affiliation:
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Department of Neurology and Neurobiology of Aging, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, 920-8641, Japan. yoshita@med.kanazawa-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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3-Iodobenzylguanidine
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diagnostic use*,
pharmacokinetics Aged Aged, 80 and over Alzheimer Disease / diagnosis*, physiopathology* Diagnosis, Differential Female Heart / physiopathology*, radionuclide imaging* Humans Hypotension, Orthostatic / diagnosis Lewy Body Disease / diagnosis*, physiopathology* Male Middle Aged Myocardium Neuropsychological Tests Radionuclide Imaging / methods Radiopharmaceuticals / diagnostic use*, pharmacokinetics Sympathetic Nervous System / physiopathology* Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 77679-27-7/3-Iodobenzylguanidine |
| Comments/Corrections | |
Comment In:
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J Neurol Neurosurg Psychiatry. 2001 Nov;71(5):574-5
[PMID:
11606662
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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