Document Detail


The clinical potential and challenges of sequencing cancer genomes for personalized medical genomics.
MedLine Citation:
PMID:  21046525     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Next-generation sequencing is revolutionizing the way in which genomic-scale biological research is performed, and its effects are beginning to be translated medically. Large-scale international collaborations for the comprehensive sequencing of the genome, epigenome, and transcriptomes of cancers and corresponding 'normal' (germ-line) DNA are heralding the start of personalized medical genomics. The promise of eliminating conjecture when determining treatment approaches is certainly appealing for both patients and clinicians; however, several major issues must be resolved before next-generation sequencing will be adopted as a routine clinical tool for patients. This feature review explores the clinical potential and challenges of studying cancer genomes for personalized medical genomics.
Authors:
Nicole Cloonan; Nic Waddell; Sean M Grimmond
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  IDrugs : the investigational drugs journal     Volume:  13     ISSN:  2040-3410     ISO Abbreviation:  IDrugs     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883655     Medline TA:  IDrugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  778-81     Citation Subset:  IM    
Affiliation:
The University of Queensland, Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, 306 Carmody Road, St Lucia, QLD 4072, Australia. n.cloonan@uq.edu.au
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