Document Detail

The clinical potential and challenges of sequencing cancer genomes for personalized medical genomics.
MedLine Citation:
PMID:  21046525     Owner:  NLM     Status:  In-Process    
Next-generation sequencing is revolutionizing the way in which genomic-scale biological research is performed, and its effects are beginning to be translated medically. Large-scale international collaborations for the comprehensive sequencing of the genome, epigenome, and transcriptomes of cancers and corresponding 'normal' (germ-line) DNA are heralding the start of personalized medical genomics. The promise of eliminating conjecture when determining treatment approaches is certainly appealing for both patients and clinicians; however, several major issues must be resolved before next-generation sequencing will be adopted as a routine clinical tool for patients. This feature review explores the clinical potential and challenges of studying cancer genomes for personalized medical genomics.
Nicole Cloonan; Nic Waddell; Sean M Grimmond
Related Documents :
16339365 - Fish genomics and biology.
23955855 - Cloning, expression and biocharacterization of ofcht5, the chitinase from the insect os...
11778865 - Bioinformatic tools for dna/protein sequence analysis, functional assignment of genes a...
23852385 - A new system for comparative functional genomics of saccharomyces yeasts.
22923125 - Aspergillus cibarius sp. nov., from traditional meju in korea.
1766435 - Molecular cloning of the uay regulatory gene of aspergillus nidulans reveals a favoured...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  IDrugs : the investigational drugs journal     Volume:  13     ISSN:  2040-3410     ISO Abbreviation:  IDrugs     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883655     Medline TA:  IDrugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  778-81     Citation Subset:  IM    
The University of Queensland, Queensland Centre for Medical Genomics, Institute for Molecular Bioscience, 306 Carmody Road, St Lucia, QLD 4072, Australia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Using large-scale RNAi screens to identify novel drug targets for cancer.
Next Document:  Lixivaptan, a non-peptide vasopressin V2 receptor antagonist for the potential oral treatment of hyp...