Document Detail

A clinical pilot study of lignin--ascorbic acid combination treatment of herpes simplex virus.
MedLine Citation:
PMID:  20023248     Owner:  NLM     Status:  MEDLINE    
Antiviral drugs as well as natural remedies have been used to reduce symptoms and the rate of recurrences of herpes simplex virus type 1 (HSV-1) infection, a common disease. To evaluate anti-HSV-1 activity of a pine cone lignin and ascorbic acid treatment, a clinical pilot study was carried out. Forty-eight healthy patients of both genders between 4 and 61 years old (mean: 31+/-16 years), with active lesions of HSV-1, took part in the study. According to the HSV-1 stage at the presentation, the patients were classified into the prodromic (16 patients), erythema (11 patients), papule edema (1 patient), vesicle/pustule (13 patients) and ulcer stages (7 patients). One mg of lignin-ascorbic acid tablet or solution was orally administered three times daily for a month. Clinical evaluations were made daily the first week and at least three times a week during the second week after the onset and every six months during the subsequent year to identify recurrence episodes. The patients who began the lignin-ascorbic acid treatment within the first 48 hours of symptom onset did not develop HSV-1 characteristic lesions, whereas those patients who began the treatment later experienced a shorter duration of cold sore lesions and a decrease in the symptoms compared with previous episodes. The majority of the patients reported the reduction in the severity of symptoms and the reduction in the recurrence episodes after the lignin-ascorbic acid treatment compared with previous episodes, suggesting its possible applicability for the prevention and treatment of HSV-1 infection.
Blanca Silvia Gonzalez Lopez; Masaji Yamamoto; Katsuaki Utsumi; Chiaki Aratsu; Hiroshi Sakagami
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  In vivo (Athens, Greece)     Volume:  23     ISSN:  0258-851X     ISO Abbreviation:  In Vivo     Publication Date:    2009 Nov-Dec
Date Detail:
Created Date:  2009-12-21     Completed Date:  2010-03-11     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8806809     Medline TA:  In Vivo     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  1011-6     Citation Subset:  IM    
Laboratoria de Patologia Bucal, Facultad de Odontologia, Universidad Autonoma del Estado de Mexico, Mexico.
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MeSH Terms
Administration, Oral
Antiviral Agents / therapeutic use*
Ascorbic Acid / therapeutic use*
Child, Preschool
Drug Therapy, Combination
Herpes Labialis / diagnosis,  drug therapy*
Lignin / therapeutic use*
Middle Aged
Pilot Projects
Pinus / chemistry*
Plant Extracts / therapeutic use
Recurrence / prevention & control
Young Adult
Reg. No./Substance:
0/Antiviral Agents; 0/Plant Extracts; 50-81-7/Ascorbic Acid; 9005-53-2/Lignin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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