| The clinical pharmacology of angiotensin converting enzyme inhibitors in chronic heart failure. | |
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MedLine Citation:
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PMID: 1641405 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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ACE inhibitors (ACEIs) have now been shown to improve symptoms and survival in patients with mild, moderate and severe chronic heart failure. Their mechanism of action is thought to be a combination of RAAS suppression and augmentation of bradykinin and prostaglandins. Although ACE inhibitors improve hemodynamics post myocardial infarction, we do not yet have consistent data on their effects on symptoms or survival in these particular patients. One other potential benefit is their effects on reperfusion injury and free radicals. As yet only minor differences have been found to exist between different ACEIs but increasing attention is now being focussed in this direction. |
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Authors:
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A D Struthers |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Pharmacology & therapeutics Volume: 53 ISSN: 0163-7258 ISO Abbreviation: Pharmacol. Ther. Publication Date: 1992 |
Date Detail:
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Created Date: 1992-09-03 Completed Date: 1992-09-03 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7905840 Medline TA: Pharmacol Ther Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 187-97 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Clinical Pharmacology, Ninewells Hospital and Medical School, Dundee, Scotland, U.K. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensin-Converting Enzyme Inhibitors
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adverse effects,
pharmacokinetics,
therapeutic use* Biological Availability Heart Failure / drug therapy* Hemodynamics / drug effects Humans Myocardial Infarction / drug therapy Myocardial Reperfusion Injury / drug therapy |
| Chemical | |
Reg. No./Substance:
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0/Angiotensin-Converting Enzyme Inhibitors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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