Document Detail


The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy): a reappraisal.
MedLine Citation:
PMID:  7600092     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Seventeen patients with a progressive bradykinetic syndrome and post-mortem findings of neurofibrillary degeneration in cerebral cortex, subcortical nuclei and brainstem were studied. Seven fulfilled currently accepted clinical diagnostic criteria for Steele-Richardson-Olszewski syndrome, whereas the remainder who lacked supranuclear gaze palsy had alternative clinical diagnoses (idiopathic Parkinson's disease, six cases; cerebrovascular disease, two cases; Parkinson's syndrome, one case; Alzheimer's disease, one case). The clinical and pathological findings of the two groups were compared in an attempt to better define the spectrum of Steele-Richardson-Olszewski disease.
Authors:
S E Daniel; V M de Bruin; A J Lees
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Brain : a journal of neurology     Volume:  118 ( Pt 3)     ISSN:  0006-8950     ISO Abbreviation:  Brain     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-08-10     Completed Date:  1995-08-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372537     Medline TA:  Brain     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  759-70     Citation Subset:  AIM; IM    
Affiliation:
Parkinson's Disease Society Brain Tissue Bank, Institute of Neurology, London, UK.
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MeSH Terms
Descriptor/Qualifier:
Age of Onset
Aged
Alzheimer Disease / diagnosis,  pathology
Basal Ganglia / pathology*
Cerebrovascular Disorders
Diagnosis, Differential
Female
Humans
Male
Middle Aged
Neurofibrillary Tangles / ultrastructure
Ophthalmoplegia / pathology
Organ Size
Parkinson Disease / diagnosis,  pathology
Pigmentation
Retrospective Studies
Supranuclear Palsy, Progressive / diagnosis,  epidemiology,  pathology*
tau Proteins / analysis
Chemical
Reg. No./Substance:
0/tau Proteins

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