Document Detail


A clinical, neurolinguistic, and radiological study of a Chinese follow-up case with primary progressive aphasia.
MedLine Citation:
PMID:  22827556     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Primary progressive aphasia (PPA) is a progressive neurodegenerative disorder characterized by the deterioration of language functions. The Han language bears some unique features from the Latin languages; however, the features of PPA in the Han language-speaking population are not well understood. In this study, we performed a 3-year follow-up on a Han language-speaking PPA patient with corresponding changes in magnetic resonance imaging (MRI). During the early stage, linguistic analysis revealed several symptoms including difficulty with auditory comprehension, right-left disorientation, reading disorders, and agraphia, specifically the execution of serial oral instructions. This Chinese PPA patient presented with a reading disorder, but his word comprehension ability remained intact. There are two different possible modalities of incorrect writing in this case. The patient also presented with noun-verb double dissociation. The early-stage MRI showed atrophy of the left frontal lobe, which was most severe in the inferior frontal gyrus. Three years later, the patient was found to have progressive atrophy in the parietal, frontal, and temporal lobes, among which the frontal lobe remained the most severely affected region. The brain imaging of the Chinese-speaking PPA patient showed changes similar to those of a Latin language-speaking PPA patient. The prominent change was asymmetrical atrophy in the frontal and temporal lobes. This is the first report of noun-verb double dissociation existing in a Chinese-language speaking PPA patient. The dissociation may be related to an impaired function of the inferior frontal gyrus, which is likely associated with verb-naming in Chinese-speaking people. Several unique features were observed in this case, including impairment in writing ability.
Authors:
Jiong Zhou; Jian-An Wang; Biao Jiang; Wen-Juan Qiu; Bin Yan; Yin-Hua Wang
Related Documents :
22144576 - Augmented single-unit muscle sympathetic nerve activity in heart failure with chronic a...
22080616 - Association of chemerin levels in synovial fluid with the severity of knee osteoarthritis.
22139496 - Decreased serum antioxidant capacity in patients with wilson disease is associated with...
22783586 - Elevated serum chemerin levels are associated with the presence of coronary artery dise...
11505126 - Clinical relevance of caspase-1 activated cytokines in acute pancreatitis: high correla...
22133576 - Influence of non-alcoholic fatty liver disease on the prognosis in patients with colore...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-24
Journal Detail:
Title:  Neurocase     Volume:  -     ISSN:  1465-3656     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9511374     Medline TA:  Neurocase     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
a Department of Neurology, Second Affiliated Hospital, School of Medicine , Zhejiang University , HangZhou , China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Self-Reported Cognitive Impairment After Breast Cancer Treatment in Young Women from the ELIPPSE40 C...
Next Document:  A Highly Sensitive And Specific qPCR Assay For Quantification Of The Biomarker SOX11 In Mantle Cell ...