Document Detail

A clinical-morphological study on cholestatic presentation of nonalcoholic fatty liver disease.
MedLine Citation:
PMID:  15986869     Owner:  NLM     Status:  MEDLINE    
To determine the association among the clinical, biochemical, and histological features of cholestasis, we analyzed all the relevant data of the patients recorded in our non-alcoholic fatty liver disease (NAFLD) database. We selected 20 NAFLD patients with abnormal transaminase levels, with both alkaline phosphatase >500 U/L and gamma-glutamyl transpeptidase >250 U/L. Their histological features were compared with those of a group of patients with NAFLD matched for sex, age, and body mass index and of a group of patients matched for sex, body mass index and histological NAFLD grading/staging. Cases and controls satisfied, on histology, the criteria for NASH. The presence of cholestasis in our patients was correlated with injury of the bile duct epithelium, characterized by cholangitis, swelling, variable bile duct loss, and bile stasis. Compared to NAFLD patients of similar age, sex, and body mass index, the cholestatic group had total and severe histological liver impairment. When we analyzed the group of patients histologically identified on the basis of identical stage and grade severity, we could not find any evidence of significant bile damage, compared to cases, despite the control group's significantly older age. NAFLD patients with biochemical cholestasis have a histological picture of bile damage; they have more advanced histological impairment than patients matched for age, sex and body mass index.
P Sorrentino; G Tarantino; A Perrella; P Micheli; O Perrella; P Conca
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  50     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-30     Completed Date:  2005-07-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1130-5     Citation Subset:  AIM; IM    
Department of Clinical and Experimental Medicine, Federico II Medical School, Naples, Italy.
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MeSH Terms
Cholestasis, Intrahepatic / etiology,  physiopathology*
Diabetes Complications / complications
Disease Progression
Fatty Liver / complications,  physiopathology*
Liver Cirrhosis / etiology,  pathology
Middle Aged
Obesity / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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