| The clinical management of tumour lysis syndrome in haematological malignancies. | |
| | |
MedLine Citation:
|
PMID: 21554259 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Tumour lysis syndrome (TLS) is caused by the disintegration of malignant cells, usually following the instigation of chemotherapy, although it may already be established at the time of initial presentation in a minority of cases. As a direct consequence of malignant cell breakdown, intracellular ions, proteins, nucleic acids and their metabolites are released into the plasma causing the characteristic metabolic abnormalities of TLS; hyperuricaemia, hyperkalaemia, hyperphosphataemia and hypocalcaemia. In many cases the release of large amounts intracellular contents is so abrupt that the normal homeostatic mechanisms are rapidly overwhelmed and without prompt, effective management, the clinical effects of TLS soon become apparent. |
| | |
Authors:
|
Andrew Will; Eleni Tholouli |
Related Documents
:
|
2317399 - Redkino to rutland--a glimmer of glasnost. 21378479 - Acute lymphoblastic leukemia in a pediatric patient with marfan's syndrome. 21834489 - Benefit and tolerability of the coadministration of ezetimibe and atorvastatin in acute... 8209919 - Smith-lemli-opitz syndrome: biochemical before clinical diagnosis; early dietary manage... 8899279 - Scleritis associated with the fibromyalgia syndrome. 10072469 - Frey's syndrome after carotid endarterectomy. 1776639 - Autosomal recessive cerebellar hypoplasia and endosteal sclerosis: a newly recognized s... 9744359 - Lymphoscintigraphy and lymphangiography of lymphangiectasia. 2652979 - Primary leiomyosarcoma of the inferior vena cava with budd-chiari syndrome. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-5-9 |
Journal Detail:
|
Title: British journal of haematology Volume: - ISSN: 1365-2141 ISO Abbreviation: - Publication Date: 2011 May |
Date Detail:
|
Created Date: 2011-5-10 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
© 2011 Blackwell Publishing Ltd. |
Affiliation:
|
Department of Paediatric Haematology, Royal Manchester Children's Hospital, Manchester Department of Haematology, Manchester Royal Infirmary, Manchester, UK. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Guidelines on the management of haemophilia in the fetus and neonate*
Next Document: A steroid-independent regimen of bortezomib, liposomal doxorubicin and thalidomide demonstrate high ...