| The clinical management of heparin-induced thrombocytopenia. | |
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MedLine Citation:
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PMID: 9930559 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Heparin-induced thrombocytopenia (HIT) is an immunologic complication of drug therapy with potentially serious venous and arterial thrombotic sequelae. Recent studies have provided insight into the molecular and cellular basis of HIT underlying the diagnosis and treatment of this syndrome. Because various approaches to HIT treatment have resulted in mixed success, the use of heparin substitutes, other anticoagulant agents, and adjunctive therapy needs to be clarified. For patients with pre-existing conditions such as deep venous thrombosis or pulmonary embolism, new understanding of the clinicopathologic syndrome of HIT offers the promise of improved antithrombotic therapy. The participation of thrombin in HIT suggests that specific (hirudin and argatroban) thrombin inhibitors may be ideal agents for treating acute HIT. |
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Authors:
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J G Kelton |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Seminars in hematology Volume: 36 ISSN: 0037-1963 ISO Abbreviation: Semin. Hematol. Publication Date: 1999 Jan |
Date Detail:
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Created Date: 1999-06-14 Completed Date: 1999-06-14 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404514 Medline TA: Semin Hematol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 17-21 Citation Subset: IM |
Affiliation:
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McMaster University Medical Center, Ontario, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Heparin
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adverse effects* Humans Thrombocytopenia / chemically induced*, diagnosis, drug therapy* |
| Chemical | |
Reg. No./Substance:
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9005-49-6/Heparin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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