Document Detail

The clinical management of heparin-induced thrombocytopenia.
MedLine Citation:
PMID:  9930559     Owner:  NLM     Status:  MEDLINE    
Heparin-induced thrombocytopenia (HIT) is an immunologic complication of drug therapy with potentially serious venous and arterial thrombotic sequelae. Recent studies have provided insight into the molecular and cellular basis of HIT underlying the diagnosis and treatment of this syndrome. Because various approaches to HIT treatment have resulted in mixed success, the use of heparin substitutes, other anticoagulant agents, and adjunctive therapy needs to be clarified. For patients with pre-existing conditions such as deep venous thrombosis or pulmonary embolism, new understanding of the clinicopathologic syndrome of HIT offers the promise of improved antithrombotic therapy. The participation of thrombin in HIT suggests that specific (hirudin and argatroban) thrombin inhibitors may be ideal agents for treating acute HIT.
J G Kelton
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Seminars in hematology     Volume:  36     ISSN:  0037-1963     ISO Abbreviation:  Semin. Hematol.     Publication Date:  1999 Jan 
Date Detail:
Created Date:  1999-06-14     Completed Date:  1999-06-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404514     Medline TA:  Semin Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  17-21     Citation Subset:  IM    
McMaster University Medical Center, Ontario, Canada.
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MeSH Terms
Heparin / adverse effects*
Thrombocytopenia / chemically induced*,  diagnosis,  drug therapy*
Reg. No./Substance:

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