| The clinical and laboratory correlates of an increased urinary 5-hydroxyindoleacetic acid. | |
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MedLine Citation:
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PMID: 7479466 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Over a five-and-a-half-year period, there were 298 laboratory requests for urinary 5-hydroxyindoleacetic acid (5-HIAA). The clinical and laboratory associations of the 24 patients in which there were 43 urinary 5-HIAA 24-h collection results greater than the laboratory upper reference limit are detailed. Four were confirmed carcinoid tumours and two were phaeochromocytomas. Flushing was a prominent symptom in 46% and diarrhoea or altered bowel habit in 37%. Associated with the raised urinary 5-HIAA values were increased levels of 4-hydroxy-3-methoxymandelic acid and homovanillic acid in 14.3% and 21%, respectively, of those collections where the metabolites were requested. Diagnostic imaging was performed in 57%. While the specificity was 88%, 5-HIAA is relatively insensitive in the diagnosis of carcinoid tumours and a more widespread use of diagnostic imaging including isotope scanning with labelled metaiodo-benzylguanidine, vasoactive intestinal peptide and octreotide is suggested. |
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Authors:
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W P Tormey; R J FitzGerald |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Postgraduate medical journal Volume: 71 ISSN: 0032-5473 ISO Abbreviation: Postgrad Med J Publication Date: 1995 Sep |
Date Detail:
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Created Date: 1995-12-26 Completed Date: 1995-12-26 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0234135 Medline TA: Postgrad Med J Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 542-5 Citation Subset: IM |
Affiliation:
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Department of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adrenal Gland Neoplasms / urine* Adult Aged Aged, 80 and over Carcinoid Tumor / complications, diagnosis, urine* Diagnostic Imaging Diarrhea / etiology, urine Female Flushing / etiology, urine Humans Hydroxyindoleacetic Acid / urine* Ireland Male Middle Aged Pheochromocytoma / urine* Predictive Value of Tests Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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54-16-0/Hydroxyindoleacetic Acid |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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