Document Detail


The clinical and laboratory correlates of an increased urinary 5-hydroxyindoleacetic acid.
MedLine Citation:
PMID:  7479466     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Over a five-and-a-half-year period, there were 298 laboratory requests for urinary 5-hydroxyindoleacetic acid (5-HIAA). The clinical and laboratory associations of the 24 patients in which there were 43 urinary 5-HIAA 24-h collection results greater than the laboratory upper reference limit are detailed. Four were confirmed carcinoid tumours and two were phaeochromocytomas. Flushing was a prominent symptom in 46% and diarrhoea or altered bowel habit in 37%. Associated with the raised urinary 5-HIAA values were increased levels of 4-hydroxy-3-methoxymandelic acid and homovanillic acid in 14.3% and 21%, respectively, of those collections where the metabolites were requested. Diagnostic imaging was performed in 57%. While the specificity was 88%, 5-HIAA is relatively insensitive in the diagnosis of carcinoid tumours and a more widespread use of diagnostic imaging including isotope scanning with labelled metaiodo-benzylguanidine, vasoactive intestinal peptide and octreotide is suggested.
Authors:
W P Tormey; R J FitzGerald
Related Documents :
9760416 - Effects of thiamin and methionine administration in preventing cadmium-induced biochemi...
8169176 - Urinary catecholamine excretion in sexually abused girls.
6616316 - Metabolic alkalosis during immobilization in monkeys (m. nemestrina).
618646 - Simple determination of high urinary excretion of 5-hydroxyindole-3-acetic acid with fe...
8626 - Correlation of in vitro and in vivo methodology for evaluation of antacids.
12001166 - Selected amino acids protect hybridoma and cho cells from elevated carbon dioxide and o...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  71     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-12-26     Completed Date:  1995-12-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  542-5     Citation Subset:  IM    
Affiliation:
Department of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenal Gland Neoplasms / urine*
Adult
Aged
Aged, 80 and over
Carcinoid Tumor / complications,  diagnosis,  urine*
Diagnostic Imaging
Diarrhea / etiology,  urine
Female
Flushing / etiology,  urine
Humans
Hydroxyindoleacetic Acid / urine*
Ireland
Male
Middle Aged
Pheochromocytoma / urine*
Predictive Value of Tests
Sensitivity and Specificity
Chemical
Reg. No./Substance:
54-16-0/Hydroxyindoleacetic Acid
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The management of acute myocardial infarction.
Next Document:  Doubly disabled: diabetes in combination with an eating disorder.