Document Detail

The clinical and laboratory correlates of an increased urinary 5-hydroxyindoleacetic acid.
MedLine Citation:
PMID:  7479466     Owner:  NLM     Status:  MEDLINE    
Over a five-and-a-half-year period, there were 298 laboratory requests for urinary 5-hydroxyindoleacetic acid (5-HIAA). The clinical and laboratory associations of the 24 patients in which there were 43 urinary 5-HIAA 24-h collection results greater than the laboratory upper reference limit are detailed. Four were confirmed carcinoid tumours and two were phaeochromocytomas. Flushing was a prominent symptom in 46% and diarrhoea or altered bowel habit in 37%. Associated with the raised urinary 5-HIAA values were increased levels of 4-hydroxy-3-methoxymandelic acid and homovanillic acid in 14.3% and 21%, respectively, of those collections where the metabolites were requested. Diagnostic imaging was performed in 57%. While the specificity was 88%, 5-HIAA is relatively insensitive in the diagnosis of carcinoid tumours and a more widespread use of diagnostic imaging including isotope scanning with labelled metaiodo-benzylguanidine, vasoactive intestinal peptide and octreotide is suggested.
W P Tormey; R J FitzGerald
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Postgraduate medical journal     Volume:  71     ISSN:  0032-5473     ISO Abbreviation:  Postgrad Med J     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1995-12-26     Completed Date:  1995-12-26     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0234135     Medline TA:  Postgrad Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  542-5     Citation Subset:  IM    
Department of Chemical Pathology, Beaumont Hospital, Dublin 9, Ireland.
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MeSH Terms
Adrenal Gland Neoplasms / urine*
Aged, 80 and over
Carcinoid Tumor / complications,  diagnosis,  urine*
Diagnostic Imaging
Diarrhea / etiology,  urine
Flushing / etiology,  urine
Hydroxyindoleacetic Acid / urine*
Middle Aged
Pheochromocytoma / urine*
Predictive Value of Tests
Sensitivity and Specificity
Reg. No./Substance:
54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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