Document Detail

A clinical investigation to determine the effect of pressure injection on the penetration of topical methyl aminolevulinate into nodular basal cell carcinoma of the skin.
MedLine Citation:
PMID:  18197827     Owner:  NLM     Status:  MEDLINE    
This investigation considered a novel method of enhancing penetration of the topical photosensitizing agent methyl aminolevulinate (MAL) into nodular basal cell carcinomas (BCCs) using an oxygen pressure injection device. Oxygen pressure injection (OPI) is a method to drive compounds into skin using pressured oxygen. The study was an observer-blinded pilot of a single application of MAL to nBCCs, with or without the use of OPI. The BCCs were then excised at different time intervals (0-180 min) and the depth of penetration of the MAL examined using microscopic fluorescence photometry to detect the production of the naturally fluorescent active photosensitiser protoporphyrin IX (PpIX). A highly selective and homogeneous distribution of MAL-induced porphyrin fluorescence was seen in all nBCC tumors studied, and showed a high lesion-to-normal-tissue ratio with very little fluorescence in the surrounding normal tissue. Although it was difficult to compare quantitatively, as individual tumors in each of the different study groups varied, a definite trend of increase in relative tumor concentration of MAL-induced PpIX was observed over time, and this was enhanced when OPI was employed.
S M Campbell; Andrew Pye; S Horton; J Matthew; P Helliwell; A Curnow
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer     Volume:  26     ISSN:  0731-8898     ISO Abbreviation:  J. Environ. Pathol. Toxicol. Oncol.     Publication Date:  2007  
Date Detail:
Created Date:  2008-01-16     Completed Date:  2008-03-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8501420     Medline TA:  J Environ Pathol Toxicol Oncol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  295-303     Citation Subset:  IM    
Cornwall Dermatology Research, Peninsula Medical School, Truro, UK.
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MeSH Terms
Aminolevulinic Acid / administration & dosage,  analogs & derivatives*,  pharmacokinetics,  therapeutic use
Carcinoma, Basal Cell* / metabolism,  pathology,  therapy
Drug Delivery Systems / instrumentation,  methods*
Injections, Intralesional
Microscopy, Fluorescence
Photosensitizing Agents* / administration & dosage,  pharmacokinetics,  therapeutic use
Pilot Projects
Protoporphyrins / metabolism
Skin Absorption
Skin Neoplasms* / metabolism,  pathology,  therapy
Reg. No./Substance:
0/Ointments; 0/Photosensitizing Agents; 0/Protoporphyrins; 0/methyl 5-aminolevulinate; 106-60-5/Aminolevulinic Acid

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