Document Detail

A clinical investigation into the microbiological status of 'locally infected' leg ulcers.
MedLine Citation:
PMID:  20051097     Owner:  NLM     Status:  MEDLINE    
The complex interactions between patients and the microbial species that reside in their wounds are not yet fully characterised. Investigations to date have dealt with either those organisms that cause infections or those that establish long-term colonisations. The objective of this open, prospective pilot study was to quantitatively and qualitatively assess the microbiological status of 'locally infected' venous leg ulcers. Three different sampling techniques were used to recover organisms from 20 venous leg ulcers that had failed to progress towards healing and comparisons made to explore the distribution of colonised flora within the wound. In total, 116 isolates were recovered (mean of 5.8 per ulcer) with highest recovery rates seen with swabs. Greatest agreement of colonisation and counts was found between swabs and absorbent polyvinyl acetate (PVA) foam disc, and also between PVA discs and biopsies. Lowest agreement was between the distribution of anaerobes and coryneforms in swabs and biopsies, suggesting uneven vertical distribution within ulcers. No justification for using routine biopsies in locally infected venous leg ulcers was found.
Rose A Cooper; Hanar Ameen; Patricia Price; Dorothy A McCulloch; Keith G Harding
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  International wound journal     Volume:  6     ISSN:  1742-481X     ISO Abbreviation:  Int Wound J     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2010-01-06     Completed Date:  2010-03-18     Revised Date:  2010-07-21    
Medline Journal Info:
Nlm Unique ID:  101230907     Medline TA:  Int Wound J     Country:  England    
Other Details:
Languages:  eng     Pagination:  453-62     Citation Subset:  IM    
Centre for Biomedical Sciences, Cardiff School of Health Sciences, University of Wales Institute Cardiff, Western Avenue, Cardiff CF5 2YB, UK.
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MeSH Terms
Aged, 80 and over
Bacteria / isolation & purification*
Bacterial Infections / microbiology*,  pathology
Diagnosis, Differential
Leg Ulcer / microbiology*,  pathology
Middle Aged
Wound Infection / microbiology*,  pathology
Comment In:
Int Wound J. 2010 Aug;7(4):301; author reply 301-2   [PMID:  20633057 ]

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