Document Detail


A clinical investigation of the efficacy of a tooth-whitening gel.
MedLine Citation:
PMID:  14692166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this randomized, controlled, examiner-blind, parallel-group clinical study was to determine whether a tooth-whitening gel (Colgate Simply White Night Clear Whitening Gel) can significantly lighten teeth when used once daily at night, as compared with a commercially available dentifrice. Following a baseline tooth shade evaluation using the VITA Shade Guide, qualifying adult male and female subjects from the Buffalo, New York area were randomized into 2 treatment groups, which were balanced for baseline VITA Shade Guide scores, gender, and age. The treatment groups were: (1) a commercially available dentifrice only; and (2) a tooth-whitening gel in addition to a commercially available dentifrice. Subjects assigned to the 2 groups were given the dentifrice and a soft-bristled toothbrush. In addition, subjects in one of the groups were given the tooth-whitening gel. All subjects were instructed to brush their teeth for 1 minute twice daily (morning and evening) with the dentifrice. The subjects in the group also using the tooth-whitening gel were further instructed to apply the gel once daily at night, as per manufacturer instructions. Evaluations of tooth shade for each subject were repeated after 2 weeks, and again after 3 weeks of product use. In addition, evaluations of tooth shade for subjects using the tooth-whitening gel were later conducted at 6 months after product use. Seventy-five subjects complied with the protocol and completed the study. At the 2-week and 3-week examinations, subjects using the tooth-whitening gel and dentifrice exhibited statistically significant (P < .05) tooth shade lightening relative to baseline tooth shade. Furthermore, at the 2-week and 3-week examinations, subjects using the tooth-whitening gel exhibited statistically significant (P < .05) tooth shade lightening relative to subjects using only the dentifrice. In addition, the 6-month-postuse examination showed that subjects using the tooth-whitening gel exhibited statistically significant (P < .05) tooth shade lightening relative to baseline, thereby maintaining the tooth shade lightening that was evident at 3 weeks. The results of this clinical study indicate that after once-daily use at night for 2 or 3 weeks, the tooth-whitening gel provided statistically significant tooth shade lightening relative to baseline tooth shade for up to at least 6 months and also provided statistically significant tooth shade lightening relative to a commercially available dentifrice after 2 and 3 weeks of product use.
Authors:
Chester Sielski; Nicholas Conforti; Bernal Stewart; Pat Chaknis; Margaret E Petrone; William DeVizio; Anthony R Volpe; Howard M Proskin
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Compendium of continuing education in dentistry (Jamesburg, N.J. : 1995)     Volume:  24     ISSN:  1548-8578     ISO Abbreviation:  Compend Contin Educ Dent     Publication Date:  2003 Aug 
Date Detail:
Created Date:  2003-12-24     Completed Date:  2004-02-05     Revised Date:  2011-11-02    
Medline Journal Info:
Nlm Unique ID:  9600713     Medline TA:  Compend Contin Educ Dent     Country:  United States    
Other Details:
Languages:  eng     Pagination:  612-4, 616-8     Citation Subset:  D    
Affiliation:
C.F.S. Testing, Inc., Cheektowaga, New York, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Analysis of Variance
Color
Complex Mixtures
Dentifrices / therapeutic use*
Drug Combinations
Female
Follow-Up Studies
Gels
Humans
Male
Middle Aged
Oxidants / administration & dosage,  therapeutic use
Peroxides / administration & dosage,  therapeutic use
Single-Blind Method
Tooth / pathology
Tooth Bleaching / methods*
Toothbrushing / instrumentation
Urea / administration & dosage,  analogs & derivatives*,  therapeutic use
Chemical
Reg. No./Substance:
0/Colgate Simply White Clear Whitening Gel; 0/Complex Mixtures; 0/Dentifrices; 0/Drug Combinations; 0/Gels; 0/Oxidants; 0/Peroxides; 124-43-6/carbamide peroxide; 57-13-6/Urea

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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