Document Detail

The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes.
MedLine Citation:
PMID:  19542882     Owner:  NLM     Status:  MEDLINE    
In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction. Ninety-seven patients who were under aspirin therapy and hospitalized with unstable angina/non-ST elevation myocardial infarction were included in the study. Laboratory-defined aspirin sensitive and resistant groups were determined by platelet function analyzer; aspirin resistance was defined as collagen/epinephrine closure time less than 165 s. Laboratory-defined aspirin resistance was noted in 29 patients (29.9%), and non-ST elevation myocardial infarction was observed in 46 patients (47.4%). Patients in the group with laboratory-defined aspirin resistance had significantly higher thrombolysis in myocardial infarction risk scores (P < 0.001). When the details of cardiac myonecrosis markers were compared, baseline and follow-up creatine kinase-myocardial band and troponin I values were higher in laboratory-defined aspirin-resistant group. Multivariate analyses revealed that laboratory-defined aspirin resistance was an independent predictor of non-ST elevation myocardial infarction (P = 0.022). Laboratory-defined aspirin resistance is associated with non-ST elevation myocardial infarction, higher markers of cardiac necrosis and thrombolysis in myocardial infarction risk score in patients hospitalized with unstable angina/non-ST elevation myocardial infarction.
Sadik Acikel; Aylin Yildirir; Alp Aydinalp; Ugur Bal; Gamze Kaynar; Bulent Ozin; Haldun Muderrisoglu
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  20     ISSN:  1473-5733     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  England    
Other Details:
Languages:  eng     Pagination:  427-32     Citation Subset:  IM    
Faculty of Medicine, Department of Cardiology, Ministry of Health Di??kapi Yildirim Beyazit Research and Educational Hospital, Baskent University, Ankara, Turkey.
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MeSH Terms
Acute Coronary Syndrome / blood*,  complications,  drug therapy,  pathology
Angina, Unstable / blood,  epidemiology
Aspirin / pharmacology*,  therapeutic use
Drug Resistance
Inflammation / blood,  epidemiology
Middle Aged
Myocardial Infarction / blood*,  epidemiology,  etiology,  pathology
Myocardium / pathology
Platelet Activation / drug effects*
Platelet Aggregation Inhibitors / pharmacology*,  therapeutic use
Platelet Function Tests / instrumentation
Risk Factors
Severity of Illness Index
Thrombophilia / blood,  epidemiology
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin

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