| The clinical importance of laboratory-defined aspirin resistance in patients presenting with non-ST elevation acute coronary syndromes. | |
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MedLine Citation:
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PMID: 19542882 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study, we aimed to assess the factors associated with laboratory-defined aspirin resistance and the relationship of this laboratory-defined aspirin resistance with thrombolysis in myocardial infarction risk score, markers of cardiac necrosis, and inflammatory and thrombotic risk factors in patients with unstable angina or non-ST elevation myocardial infarction. Ninety-seven patients who were under aspirin therapy and hospitalized with unstable angina/non-ST elevation myocardial infarction were included in the study. Laboratory-defined aspirin sensitive and resistant groups were determined by platelet function analyzer; aspirin resistance was defined as collagen/epinephrine closure time less than 165 s. Laboratory-defined aspirin resistance was noted in 29 patients (29.9%), and non-ST elevation myocardial infarction was observed in 46 patients (47.4%). Patients in the group with laboratory-defined aspirin resistance had significantly higher thrombolysis in myocardial infarction risk scores (P < 0.001). When the details of cardiac myonecrosis markers were compared, baseline and follow-up creatine kinase-myocardial band and troponin I values were higher in laboratory-defined aspirin-resistant group. Multivariate analyses revealed that laboratory-defined aspirin resistance was an independent predictor of non-ST elevation myocardial infarction (P = 0.022). Laboratory-defined aspirin resistance is associated with non-ST elevation myocardial infarction, higher markers of cardiac necrosis and thrombolysis in myocardial infarction risk score in patients hospitalized with unstable angina/non-ST elevation myocardial infarction. |
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Authors:
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Sadik Acikel; Aylin Yildirir; Alp Aydinalp; Ugur Bal; Gamze Kaynar; Bulent Ozin; Haldun Muderrisoglu |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis Volume: 20 ISSN: 1473-5733 ISO Abbreviation: Blood Coagul. Fibrinolysis Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-08-13 Completed Date: 2009-12-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9102551 Medline TA: Blood Coagul Fibrinolysis Country: England |
Other Details:
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Languages: eng Pagination: 427-32 Citation Subset: IM |
Affiliation:
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Faculty of Medicine, Department of Cardiology, Ministry of Health Di??kapi Yildirim Beyazit Research and Educational Hospital, Baskent University, Ankara, Turkey. sadik.acikel@tkd.org.tr |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Coronary Syndrome
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blood*,
complications,
drug therapy,
pathology Aged Angina, Unstable / blood, epidemiology Aspirin / pharmacology*, therapeutic use Comorbidity Drug Resistance Electrocardiography Female Humans Inflammation / blood, epidemiology Male Middle Aged Myocardial Infarction / blood*, epidemiology, etiology, pathology Myocardium / pathology Necrosis Platelet Activation / drug effects* Platelet Aggregation Inhibitors / pharmacology*, therapeutic use Platelet Function Tests / instrumentation Risk Factors Severity of Illness Index Thrombophilia / blood, epidemiology |
| Chemical | |
Reg. No./Substance:
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0/Platelet Aggregation Inhibitors; 50-78-2/Aspirin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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