Document Detail

The clinical importance of hypochlorhydria (a consequence of chronic Helicobacter infection): its possible etiological role in mineral and amino acid malabsorption, depression, and other syndromes.
MedLine Citation:
PMID:  1494327     Owner:  NLM     Status:  MEDLINE    
In a previous paper evidence was presented to show that Helicobacter-induced chronic gastritis is the probable cause of most chronic hypochlorhydria. In this article evidence is presented for the clinical relevance of reduced stomach acid secretion. Reduced mineral absorption is fairly well documented and has sound theoretical support from basic chemistry. Impaired digestion of protein has been suggested by a few studies. Small intestinal bacterial overgrowth in hypochlorhydria probably leads to putrefactive breakdown of the metobolically useful products of protein digestion, thereby reducing their availability for certain essential pathways. The possible lowering of tryptophan, tyrosine, and phenylalanine in the blood may be a precipitating factor in depression in hypochlorhydric patients. In reduced or absent stomach acid secretion a constellation of gastrointestinal symptoms has been consistently observed and reported by clinicians in the past, and treatment of the hypochlorhydria with hydrochloric acid or its substitutes has often been observed to be effective in reducing these symptoms.
R E Cater
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical hypotheses     Volume:  39     ISSN:  0306-9877     ISO Abbreviation:  Med. Hypotheses     Publication Date:  1992 Dec 
Date Detail:
Created Date:  1993-03-05     Completed Date:  1993-03-05     Revised Date:  2008-08-15    
Medline Journal Info:
Nlm Unique ID:  7505668     Medline TA:  Med Hypotheses     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  375-83     Citation Subset:  IM    
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MeSH Terms
Achlorhydria / complications*,  microbiology*
Amino Acids / metabolism*
Chronic Disease
Depression / etiology*,  microbiology
Dietary Proteins
Helicobacter Infections / complications*
Malabsorption Syndromes / etiology*,  microbiology
Minerals / metabolism*
Reg. No./Substance:
0/Amino Acids; 0/Dietary Proteins; 0/Minerals

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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