Document Detail

The clinical implications of the CHICAGO study for the management of cardiovascular risk in patients with type 2 diabetes mellitus.
MedLine Citation:
PMID:  19679266     Owner:  NLM     Status:  MEDLINE    
The CHICAGO study (Carotid Intima-Media Thickness in Atherosclerosis Using Pioglitazone) tested the hypothesis that pioglitazone would have a beneficial effect for reducing CIMT progression, compared with glimepiride. Treatment with pioglitazone produced improvement in several parameters, such as systolic blood pressure and lipid levels, including a 14% increase in HDL cholesterol, and reduced CIMT progression, compared with glimepiride. However, only the beneficial effect on HDL cholesterol predicted its beneficial effect for reducing CIMT progression. The following review examines data from additional studies evaluating how pioglitazone and HDL levels modify cardiovascular risk.
Tamar Polonsky; Theodore Mazzone; Michael Davidson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Trends in cardiovascular medicine     Volume:  19     ISSN:  1873-2615     ISO Abbreviation:  Trends Cardiovasc. Med.     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-08-14     Completed Date:  2009-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9108337     Medline TA:  Trends Cardiovasc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  94-9     Citation Subset:  IM    
Pritzker School of Medicine, The University of Chicago, Chicago, IL, USA.
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MeSH Terms
Carotid Arteries / drug effects
Cholesterol, HDL / blood
Diabetes Mellitus, Type 2 / blood,  drug therapy*
Diabetic Angiopathies / prevention & control*
Hypoglycemic Agents / therapeutic use*
Randomized Controlled Trials as Topic
Sulfonylurea Compounds / therapeutic use
Thiazolidinediones / therapeutic use*
Tunica Intima / drug effects*
Reg. No./Substance:
0/Cholesterol, HDL; 0/Hypoglycemic Agents; 0/Sulfonylurea Compounds; 0/Thiazolidinediones; 111025-46-8/pioglitazone; 93479-97-1/glimepiride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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