| The clinical and hemodynamic factors that influence the concentrations of biomarkers of myocyte injury measured by high sensitive assay PATHFAST. | |
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MedLine Citation:
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PMID: 19167634 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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BACKGROUND: Subclinical myocyte injury plays an important role in the progression of congestive heart failure. However, the clinical and hemodynamic factors that influence the concentrations of biomarkers of myocyte injury have not been clarified. METHODS: Blood was sampled during diagnostic cardiac catheterization from 108 consecutive patients without acute coronary syndrome and acute cardiac decompensation. The serum concentrations of B-type natriuretic peptide (BNP), cardiac troponin I (cTnI), creatine kinase (CK)-MB, and myoglobin were measured simultaneously by high sensitive PATHFAST assay. Single and multiple variable regression analyses were carried out in search of correlations between clinical and hemodynamic variables and concentrations of biomarkers. RESULTS: By multiple variable analysis, hemoglobin concentration, pulmonary capillary wedge pressure (PCWP), left ventricular (LV) ejection fraction, and estimated glomerular filtration rate (GFR) were independently correlated with a BNP concentration ≥ median 72.1 pg/ml. The only factors independently correlated with a concentration of cTnI ≥ median 0.01 ng/ml were PCWP and estimated GFR. Cardiac index emerged as a single, powerful, independent correlate of CK-MB concentration ≥ median 0.66 ng/ml, and estimated GFR emerged as a single independent correlate of myoglobin concentration ≥ median 40.1 ng/ml. CONCLUSIONS: Clinical and hemodynamic factors influence the concentrations of BNP, cTnI, CK-MB, and myoglobin. These factors should be considered when interpreting the concentrations of these biochemical markers. |
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Authors:
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Yukihito Sato; Tadashi Miyamoto; Ryoji Taniguchi; Kazuya Nagao; Tatsuhiko Matsuoka; Rei Fukuhara; Yasuhide Kuwabara; Kei Isoda; Keiichiro Yamane; Kiyoto Nishi; Sayaka Saijyo; Hisayoshi Fujiwara; Yoshiki Takatsu |
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Publication Detail:
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Type: Journal Article Date: 2008-10-05 |
Journal Detail:
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Title: Journal of cardiology Volume: 53 ISSN: 1876-4738 ISO Abbreviation: J Cardiol Publication Date: 2009 Feb |
Date Detail:
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Created Date: 2009-01-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: Japan |
Other Details:
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Languages: eng Pagination: 20-7 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Hyogo Prefectural Amagasaki Hospital, Amagasaki, Hyogo, Japan. cardioys@kuhp.kyoto-u.ac.jp |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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