Document Detail

A clinical and genetic study of familial Parkinson's disease.
MedLine Citation:
PMID:  1922124     Owner:  NLM     Status:  MEDLINE    
The clinical features of familial Parkinson's disease (PD) were investigated by examining the families of 20 British probands who were selected on the basis of having clinically typical PD and at least one affected relative. Forty-nine secondary cases were identified. These subjects were clinically indistinguishable from sporadic cases of idiopathic PD. If it is assumed that familial PD has a genetic basis, pedigree and segregation analysis suggested autosomal dominant inheritance of a gene or genes with reduced penetrance as the most likely explanation. The data did not support the possibilities of either mitochondrial or polygenic inheritance, although the latter cannot be excluded. The role of genetic factors in sporadic cases of PD remains unclear.
D M Maraganore; A E Harding; C D Marsden
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  6     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-07     Completed Date:  1991-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
University Department of Clinical Neurology, Institute of Neurology, London, England.
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MeSH Terms
Data Interpretation, Statistical
Follow-Up Studies
Genes, Dominant / genetics
Middle Aged
Models, Genetic
Parkinson Disease / genetics*

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