Document Detail


A clinical and genetic study of familial Parkinson's disease.
MedLine Citation:
PMID:  1922124     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical features of familial Parkinson's disease (PD) were investigated by examining the families of 20 British probands who were selected on the basis of having clinically typical PD and at least one affected relative. Forty-nine secondary cases were identified. These subjects were clinically indistinguishable from sporadic cases of idiopathic PD. If it is assumed that familial PD has a genetic basis, pedigree and segregation analysis suggested autosomal dominant inheritance of a gene or genes with reduced penetrance as the most likely explanation. The data did not support the possibilities of either mitochondrial or polygenic inheritance, although the latter cannot be excluded. The role of genetic factors in sporadic cases of PD remains unclear.
Authors:
D M Maraganore; A E Harding; C D Marsden
Related Documents :
12067634 - Parkinson's disease: one biochemical pathway to fit all genes?
20625164 - Eye movement disorders are different in parkin-linked and idiopathic early-onset pd.
17674414 - Rapid and reliable detection of exon rearrangements in various movement disorders genes...
18413474 - Parietal lobe deficits in frontotemporal lobar degeneration caused by a mutation in the...
17570134 - Comp mutations: domain-dependent relationship between abnormal chondrocyte trafficking ...
10955954 - Hla and beta-myosin heavy chain do not influence susceptibility to chagas disease cardi...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  6     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1991  
Date Detail:
Created Date:  1991-11-07     Completed Date:  1991-11-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-11     Citation Subset:  IM    
Affiliation:
University Department of Clinical Neurology, Institute of Neurology, London, England.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Data Interpretation, Statistical
Family*
Female
Follow-Up Studies
Genes, Dominant / genetics
Humans
Male
Middle Aged
Models, Genetic
Parkinson Disease / genetics*
Pedigree

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Modeling the functional organization of the basal ganglia. A parallel distributed processing approac...
Next Document:  Absorption of apomorphine by various routes in parkinsonism.