Document Detail


A clinical focus on statins.
MedLine Citation:
PMID:  11575709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Clinical trials have demonstrated that inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase (statins) significantly reduce cardiovascular-related morbidity and mortality in patients with and without coronary artery disease. Furthermore, statins are currently the most potent cholesterol-lowering drugs available. Subanalyses of the LIPID study have shown that patients suffering from unstable angina pectoris had at least the same benefit from statin therapy as did patients after myocardial infarction. Studies, recently published (AVERT or MIRACL) provide more information on the topic of therapy with statins in the early phase of acute coronary syndromes.
Authors:
J Auer; B Eber
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Publication Detail:
Type:  Comparative Study; Journal Article; Review    
Journal Detail:
Title:  Current opinion in investigational drugs (London, England : 2000)     Volume:  2     ISSN:  1472-4472     ISO Abbreviation:  Curr Opin Investig Drugs     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-09-28     Completed Date:  2001-12-04     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100965718     Medline TA:  Curr Opin Investig Drugs     Country:  England    
Other Details:
Languages:  eng     Pagination:  382-8     Citation Subset:  IM    
Affiliation:
IInd Medicine Department with Cardiology and Intensive Care, General Hospital Wels, Austria. johann.auer@khwels.at
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MeSH Terms
Descriptor/Qualifier:
Angina Pectoris / drug therapy,  therapy
Angioplasty, Transluminal, Percutaneous Coronary
Anticholesteremic Agents / economics,  therapeutic use*
Cholesterol / biosynthesis,  blood
Cholesterol, LDL / blood,  metabolism
Clinical Trials as Topic
Coronary Disease / drug therapy*,  metabolism,  mortality
Cost-Benefit Analysis
Down-Regulation
Fatty Acids, Monounsaturated / therapeutic use
Heptanoic Acids / therapeutic use
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / economics,  therapeutic use*
Indoles / therapeutic use
Lovastatin / therapeutic use
Multicenter Studies as Topic
Myocardial Infarction / drug therapy*,  metabolism
Practice Guidelines as Topic
Pravastatin / therapeutic use
Pyrroles / therapeutic use
Quality of Life
Randomized Controlled Trials as Topic
Simvastatin / therapeutic use
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, LDL; 0/Fatty Acids, Monounsaturated; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Indoles; 0/Pyrroles; 110862-48-1/atorvastatin; 57-88-5/Cholesterol; 75330-75-5/Lovastatin; 79902-63-9/Simvastatin; 81093-37-0/Pravastatin; 93957-54-1/fluvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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