Document Detail

The clinical features and surgical outcomes of pediatric patients with primary spinal cord tumor.
MedLine Citation:
PMID:  22447490     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Primary spinal cord tumors (PSCTs) in pediatric patients are rare, with a reported overall incidence rate of 1-2.6 per one million children. We reviewed our experience of surgically treated 27 pediatric patients with PSCT and discussed the clinical features, radiological findings, surgical outcomes, and prognostic factors.
METHODS: Between March 1999 and March 2010, a total of 27 pediatric patients with PSCT were surgically treated in a single institution. We retrospectively analyzed their data.
RESULTS: There were 13 females and 14 males, and their ages ranged from 6 months to 19 years (mean age, 12.1 years). The most common presenting symptom was motor weakness, and the histologic type of the tumors were mainly schwannoma, astrocytoma, and ependymoma. The tumor was completely resected in 17 patients, subtotally resected in 7 patients, and partial resection or biopsy was performed in 3 patients. Adjuvant chemotherapy was performed in 9 patients, and radiotherapy in 12 patients, respectively. The average follow-up period was 33.5 months (1.17-129). Five patients experienced the progression of disease, and three of them expired. The mean time for disease progression was 19.0 months (4.5-48.7).
CONCLUSIONS: PSCT in pediatric patients can be surgically removed with an acceptable low surgical morbidity. Progression-free survival was found to be related to the grade of tumor and the extent of tumor resection. Early diagnosis and treatment anticipate good functional neurologic outcome.
Gwi Hyun Choi; Jae Keun Oh; Tae Yup Kim; Nam Kyu You; Hyo Sang Lee; Do Heum Yoon; Yoon Ha; Seong Yi; Dong Seok Kim; Joong Uhn Choi; Keung Nyun Kim
Publication Detail:
Type:  Journal Article     Date:  2012-03-25
Journal Detail:
Title:  Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery     Volume:  28     ISSN:  1433-0350     ISO Abbreviation:  Childs Nerv Syst     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-05-28     Completed Date:  2012-09-21     Revised Date:  2014-02-21    
Medline Journal Info:
Nlm Unique ID:  8503227     Medline TA:  Childs Nerv Syst     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  897-904     Citation Subset:  IM    
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MeSH Terms
Astrocytoma / mortality,  pathology,  surgery
Chemotherapy, Adjuvant
Child, Preschool
Disease-Free Survival
Ependymoma / mortality,  pathology,  surgery
Kaplan-Meier Estimate
Magnetic Resonance Imaging
Neurilemmoma / mortality,  pathology,  surgery
Neurosurgical Procedures
Radiotherapy, Adjuvant
Retrospective Studies
Spinal Cord Neoplasms / mortality,  pathology*,  surgery*
Treatment Outcome
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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