| The clinical and endocrine outcome to trans-sphenoidal microsurgery of nonsecreting pituitary adenomas. | |
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MedLine Citation:
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PMID: 1855185 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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From 1962 to 1987, 126 patients underwent trans-sphenoidal surgery for primary treatment of pituitary adenomas unassociated with clinical or biochemical evidence of hormonal overproduction. There were 73 male and 53 female patients (mean age, 50 +/- 12 years). Before surgery, 56% of the patients (70 of 124) had headaches, 74% (94 of 126) had deterioration of vision, and 12% (15 of 126) had ophthalmoplegia. Endocrine evaluation revealed the presence of hypogonadism in 75% (87 of 115), adrenal insufficiency in 36% (46 of 126), and hypothyroidism in 18% (21 of 122). Plasma prolactin was increased in 65% (56 of 86) with a mean level of 39 +/- 14 micrograms/l (normal, 3 to 20 micrograms/l). Radiologic enlargement of the sella turcica was documented in all cases: 67% (84 of 126) had enclosed and 33% (42 of 126) had invasive adenomas. After surgery, vision was normalized or improved in 75% (71 of 94) of the patients. Thyroid, adrenal, and gonadal functions were improved in 14% (three of 22), 41% (19 of 46), 11% (ten of 87), were unchanged in 82% (100 of 122), 77% (97 of 126), 89% (102 of 115), and worsened in 15% (19 of 22), 8% (ten of 126), 3% (102 of 115), respectively. Permanent diabetes insipidus occurred in 5% (seven of 126). Two patients died during the immediate postoperative period. The recurrence rate in patients with a mean follow-up of 6.4 +/- 4.2 years was 21% (15 of 71). These data indicate that trans-sphenoidal microsurgery is an effective and safe initial treatment for patients with nonsecreting pituitary adenoma and may reverse hypopituitarism. |
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Authors:
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R Comtois; H Beauregard; M Somma; O Serri; N Aris-Jilwan; J Hardy |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Cancer Volume: 68 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1991 Aug |
Date Detail:
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Created Date: 1991-08-28 Completed Date: 1991-08-28 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 860-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, Notre-Dame Hospital, University of Montréal, Canada. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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complications,
surgery* Adolescent Adrenal Insufficiency / etiology Adult Aged Child Endocrine System Diseases / etiology, surgery* Female Follow-Up Studies Headache / etiology Humans Hypogonadism / etiology Hypothyroidism / etiology Male Microsurgery Middle Aged Pituitary Neoplasms / complications, surgery* Postoperative Complications Recurrence Sphenoid Bone Vision Disorders / etiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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