Document Detail

The clinical effectiveness of negative pressure wound therapy: a systematic review.
MedLine Citation:
PMID:  21135797     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the efficacy of negative pressure wound therapy (NPWT), on the basis of a systematic review of reported randomised controlled trials (RCTs).
METHOD: A systematic literature search for relevant RCTs was carried out. The credibility of the outcome of each study was evaluated using a specially constructed instrument.
RESULTS: We identified 17 RCTs, of which five had not been included in previous reviews or health technology assessments. For diabetic foot ulcers (seven RCTs), there was consistent evidence of the benefit of NPWT compared with control treatments. For pressure ulcers (three RCTs), results were conflicting. In trials involving mixed wounds (five RCTs), evidence was encouraging but of inadequate quality. Significant complications were not increased.
CONCLUSION: There is now sufficient evidence to show that NPWT is safe, and will accelerate healing, to justify its use in the treatment of diabetes-associated chronic leg wounds. There is also evidence, though of poor quality, to suggest that healing of other wounds may also be accelerated.
X Xie; M McGregor; N Dendukuri
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of wound care     Volume:  19     ISSN:  0969-0700     ISO Abbreviation:  J Wound Care     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-07     Completed Date:  2011-01-06     Revised Date:  2011-03-10    
Medline Journal Info:
Nlm Unique ID:  9417080     Medline TA:  J Wound Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  490-5     Citation Subset:  N    
Department of Medicine, I McGill University Health Centre, Montreal, Quebec, Canada.
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MeSH Terms
Acute Disease
Chronic Disease
Diabetic Foot / therapy
Evidence-Based Practice
Negative-Pressure Wound Therapy / adverse effects,  instrumentation,  methods*
Pressure Ulcer / therapy
Randomized Controlled Trials as Topic
Research Design
Technology Assessment, Biomedical
Treatment Outcome
Wound Healing*
Wounds and Injuries / therapy*
Comment In:
J Wound Care. 2011 Feb;20(2):88, author reply 88-9   [PMID:  21378684 ]
Erratum In:
J Wound Care. 2011 Feb;20(2):89

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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