| The clinical effectiveness of negative pressure wound therapy: a systematic review. | |
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MedLine Citation:
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PMID: 21135797 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To estimate the efficacy of negative pressure wound therapy (NPWT), on the basis of a systematic review of reported randomised controlled trials (RCTs). METHOD: A systematic literature search for relevant RCTs was carried out. The credibility of the outcome of each study was evaluated using a specially constructed instrument. RESULTS: We identified 17 RCTs, of which five had not been included in previous reviews or health technology assessments. For diabetic foot ulcers (seven RCTs), there was consistent evidence of the benefit of NPWT compared with control treatments. For pressure ulcers (three RCTs), results were conflicting. In trials involving mixed wounds (five RCTs), evidence was encouraging but of inadequate quality. Significant complications were not increased. CONCLUSION: There is now sufficient evidence to show that NPWT is safe, and will accelerate healing, to justify its use in the treatment of diabetes-associated chronic leg wounds. There is also evidence, though of poor quality, to suggest that healing of other wounds may also be accelerated. |
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Authors:
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X Xie; M McGregor; N Dendukuri |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of wound care Volume: 19 ISSN: 0969-0700 ISO Abbreviation: J Wound Care Publication Date: 2010 Nov |
Date Detail:
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Created Date: 2010-12-07 Completed Date: 2011-01-06 Revised Date: 2011-03-10 |
Medline Journal Info:
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Nlm Unique ID: 9417080 Medline TA: J Wound Care Country: England |
Other Details:
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Languages: eng Pagination: 490-5 Citation Subset: N |
Affiliation:
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Department of Medicine, I McGill University Health Centre, Montreal, Quebec, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Chronic Disease Diabetic Foot / therapy Evidence-Based Practice Humans Negative-Pressure Wound Therapy / adverse effects, instrumentation, methods* Pressure Ulcer / therapy Randomized Controlled Trials as Topic Research Design Safety Technology Assessment, Biomedical Treatment Outcome Wound Healing* Wounds and Injuries / therapy* |
| Comments/Corrections | |
Comment In:
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J Wound Care. 2011 Feb;20(2):88, author reply 88-9
[PMID:
21378684
]
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Erratum In:
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J Wound Care. 2011 Feb;20(2):89 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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