Document Detail

The clinical effectiveness of negative pressure wound therapy: a systematic review.
MedLine Citation:
PMID:  21135797     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To estimate the efficacy of negative pressure wound therapy (NPWT), on the basis of a systematic review of reported randomised controlled trials (RCTs).
METHOD: A systematic literature search for relevant RCTs was carried out. The credibility of the outcome of each study was evaluated using a specially constructed instrument.
RESULTS: We identified 17 RCTs, of which five had not been included in previous reviews or health technology assessments. For diabetic foot ulcers (seven RCTs), there was consistent evidence of the benefit of NPWT compared with control treatments. For pressure ulcers (three RCTs), results were conflicting. In trials involving mixed wounds (five RCTs), evidence was encouraging but of inadequate quality. Significant complications were not increased.
CONCLUSION: There is now sufficient evidence to show that NPWT is safe, and will accelerate healing, to justify its use in the treatment of diabetes-associated chronic leg wounds. There is also evidence, though of poor quality, to suggest that healing of other wounds may also be accelerated.
X Xie; M McGregor; N Dendukuri
Related Documents :
3663447 - Circulatory and respiratory effects of infused adenosine in conscious man.
25158887 - Cavopulmonary assist for the failing fontan circulation: impact of ventricular function...
2590907 - Mechanism of the apparent parasympathetic inhibition of adenosine induced heart rate sl...
25213687 - Aldosterone, cognitive function, and cerebral hemodynamics in hypertension and antihype...
2714157 - Pulmonary oxygen toxicity in the guinea pig. effect of indomethacin.
9733357 - Effects of sumatriptan on coronary flow and left ventricular function in the isolated p...
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of wound care     Volume:  19     ISSN:  0969-0700     ISO Abbreviation:  J Wound Care     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-12-07     Completed Date:  2011-01-06     Revised Date:  2011-03-10    
Medline Journal Info:
Nlm Unique ID:  9417080     Medline TA:  J Wound Care     Country:  England    
Other Details:
Languages:  eng     Pagination:  490-5     Citation Subset:  N    
Department of Medicine, I McGill University Health Centre, Montreal, Quebec, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Acute Disease
Chronic Disease
Diabetic Foot / therapy
Evidence-Based Practice
Negative-Pressure Wound Therapy / adverse effects,  instrumentation,  methods*
Pressure Ulcer / therapy
Randomized Controlled Trials as Topic
Research Design
Technology Assessment, Biomedical
Treatment Outcome
Wound Healing*
Wounds and Injuries / therapy*
Comment In:
J Wound Care. 2011 Feb;20(2):88, author reply 88-9   [PMID:  21378684 ]
Erratum In:
J Wound Care. 2011 Feb;20(2):89

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Salvage of Charcot foot neuropathy superimposed with osteomyelitis: a case report.
Next Document:  Clinical experience of a new NPWT system in diabetic foot ulcers and post-amputation wounds.