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The clinical diagnostic significance of cerebrospinal fluid D-Lactate for bacterial meningitis.
MedLine Citation:
PMID:  22713513     Owner:  NLM     Status:  Publisher    
BACKGROUND: To study the clinical and laboratory significance of D-Lactate in the diagnosis of bacterial meningitis (BM). METHODS: The levels of D-Lactate, L-lactate, IL-6, IL-8, and other biochemical markers were determined in 83 CSF samples from different types of meningitis and the controls. RESULTS: The CSF values of D-Lactate, L-Lactate, IL-6, IL-8, erythrocytes, leukocytes, and protein were higher in patients with BM than those in the controls and patients with viral meningitis. The levels of D-Lactate, L-Lactate, IL-6, and erythrocytes in the BM group were higher than those in the tuberculous meningitis group. At the cutoff 12.8 μmol/L, D-lactate showed the diagnostic sensitivity of 94.7%. D-lactate gave the area under the curve (AUC) 0.905, which was higher than those of other markers. Using multiple marker detection, the AUC reached 0.956, which was the highest among all the parameters. Pearson correlation analysis revealed that D-Lactate was positively correlated to IL-6 and L-Lactate (r = 0.727, 0.789 and P= 0.000, 0.000, respectively). CONCLUSIONS: The CSF concentrations of D-Lactate are significantly increased in the presence of BM. Measurement of D-Lactate provides a rapid diagnosis and differential diagnosis for BM. Combination of D-Lactate with other biochemical markers improves the specificity.
Zengqiang Chen; Yumin Wang; Aibing Zeng; Lijiang Chen; Ruihao Wu; Bicheng Chen; Mengquan Chen; Jinshuang Bo; Hu Zhang; Qian Peng; Jianxin Lu; Qing H Meng
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-16
Journal Detail:
Title:  Clinica chimica acta; international journal of clinical chemistry     Volume:  -     ISSN:  1873-3492     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  1302422     Medline TA:  Clin Chim Acta     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier B.V.
Department of Laboratory Medicine, the First Affiliated Hospital of Wenzhou Medical College, Wenzhou, China.
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