Document Detail

The clinical course of Behçet's disease in pregnancy: a retrospective analysis and review of the literature.
MedLine Citation:
PMID:  12928538     Owner:  NLM     Status:  MEDLINE    
Although Behçet's disease is mainly diagnosed during the reproductive periods of life, we know little about the influence of pregnancy on the clinical course of Behçet's disease. Therefore, we analyzed the relationship between Behçet's disease and pregnancy retrospectively, in order to detect any possible interaction between the two multisystemic processes, particularly in regard to the influence of pregnancy on the clinical course of Behçet's disease. We studied 44 pregnancies in 28 women with Behçet's disease. The diagnoses were made according to the criteria of the International Study Group for Behçet's disease. The patients were observed during pregnancy and puerperium periods at monthly intervals. The existence and incidence of symptoms were recorded during these periods. There was remission of Behçet's disease during 23 (52.3%) pregnancies, although the disease had been in a stage of exacerbation before pregnancy. The disease became exacerbated during 12 (27.3%) pregnancies, although it had been in a stage of remission before pregnancy. There were no changes in the clinical course of Behçet's disease in 9 (20.4%) pregnancies. The most frequent manifestations of the clinical exacerbation were increases in the intensity and severity of outbreaks of oral ulcers during pregnancy. Outbreaks of genital ulcers, eye inflammations, and arthritis were other signs of exacerbation. Other than spontaneous abortion in three patients, we did not observe maternal or fetal complications. Although Behçet's disease tends toward remission during pregnancy, the influence of pregnancy on its clinical course is quite variable between patients and even during different pregnancies in the same patient. On the basis of our and previous results, we speculate that pregnancy in general does not seem to markedly affect the natural course of Behçet's disease.
Soner Uzun; Erkan Alpsoy; Murat Durdu; Ayse Akman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The Journal of dermatology     Volume:  30     ISSN:  0385-2407     ISO Abbreviation:  J. Dermatol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-08-20     Completed Date:  2003-09-10     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7600545     Medline TA:  J Dermatol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  499-502     Citation Subset:  IM    
Department of Dermatology, School of Medicine, Cukurova University, Adana, Turkey.
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MeSH Terms
Behcet Syndrome / physiopathology*
Gestational Age
Monitoring, Physiologic
Obstetric Labor Complications / diagnosis,  epidemiology*
Postpartum Period
Pregnancy Complications / diagnosis*,  epidemiology
Pregnancy Outcome*
Pregnancy, High-Risk*
Retrospective Studies
Risk Assessment
Severity of Illness Index
Turkey / epidemiology

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