Document Detail

A clinical comparison of two different prednisolone acetate formulations in patients undergoing cataract surgery.
MedLine Citation:
PMID:  16083539     Owner:  NLM     Status:  MEDLINE    
PURPOSE: This study was conducted to evaluate the efficacy of two topical steroid prednisolone preparations (Econopred Plus 1%, prednisolone acetate 1%: EPP; Pred Fortedagger 1%, prednisolone acetate 1%: PF) in reducing postoperative inflammation in cataract patients. METHODS: This was a 4 week, randomized, parallel-group, single-center, active-controlled study. One group of patients received postoperative topical EPP while the other group received postoperative topical PF. Both medications were dosed 4 times per day for 14 days and then BID until the container was empty. Both groups of patients received diclofenac sodium QID for 14 days and hydroxypropyl guar (HP-Guar, Systane) QID for 7 days then PRN (or as directed). The presence of corneal surface keratitis, anterior chamber cells and flare (scales 0-3 for keratitis, 0-5 for cells and 0-4 for flare; 0 = none) was evaluated by slit lamp biomicroscopy. RESULTS: EPP produced significantly lower (P < 0.05) anterior chamber flare scores 14 days following surgery (mean +/- SD: 0.86 +/- 0.53) than PF (1.08 +/- 0.40). Otherwise, there were no differences observed between the 2 treatments with respect to keratitis, anterior chamber flare or cells at postop days 1, 7, or 28. CONCLUSIONS: This comparative trial demonstrated that both formulations of prednisolone acetate 1% have similar efficacy in the treatment of postoperative ophthalmologic inflammation.
Johnny L Gayton
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Current medical research and opinion     Volume:  21     ISSN:  0300-7995     ISO Abbreviation:  Curr Med Res Opin     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-08     Completed Date:  2005-12-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0351014     Medline TA:  Curr Med Res Opin     Country:  England    
Other Details:
Languages:  eng     Pagination:  1291-5     Citation Subset:  IM    
Eyesight Associates, Warner Robins, GA, USA.
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MeSH Terms
Cataract Extraction / adverse effects*
Glucocorticoids / therapeutic use*
Inflammation / etiology,  prevention & control*
Lens Implantation, Intraocular / adverse effects
Macular Edema / etiology,  prevention & control
Postoperative Care*
Prednisolone / analogs & derivatives*,  therapeutic use
Treatment Outcome
Reg. No./Substance:
0/Glucocorticoids; 50-24-8/Prednisolone; 52-21-1/prednisolone acetate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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