| A clinical comparison of two different prednisolone acetate formulations in patients undergoing cataract surgery. | |
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MedLine Citation:
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PMID: 16083539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: This study was conducted to evaluate the efficacy of two topical steroid prednisolone preparations (Econopred Plus 1%, prednisolone acetate 1%: EPP; Pred Fortedagger 1%, prednisolone acetate 1%: PF) in reducing postoperative inflammation in cataract patients. METHODS: This was a 4 week, randomized, parallel-group, single-center, active-controlled study. One group of patients received postoperative topical EPP while the other group received postoperative topical PF. Both medications were dosed 4 times per day for 14 days and then BID until the container was empty. Both groups of patients received diclofenac sodium QID for 14 days and hydroxypropyl guar (HP-Guar, Systane) QID for 7 days then PRN (or as directed). The presence of corneal surface keratitis, anterior chamber cells and flare (scales 0-3 for keratitis, 0-5 for cells and 0-4 for flare; 0 = none) was evaluated by slit lamp biomicroscopy. RESULTS: EPP produced significantly lower (P < 0.05) anterior chamber flare scores 14 days following surgery (mean +/- SD: 0.86 +/- 0.53) than PF (1.08 +/- 0.40). Otherwise, there were no differences observed between the 2 treatments with respect to keratitis, anterior chamber flare or cells at postop days 1, 7, or 28. CONCLUSIONS: This comparative trial demonstrated that both formulations of prednisolone acetate 1% have similar efficacy in the treatment of postoperative ophthalmologic inflammation. |
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Authors:
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Johnny L Gayton |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Current medical research and opinion Volume: 21 ISSN: 0300-7995 ISO Abbreviation: Curr Med Res Opin Publication Date: 2005 Aug |
Date Detail:
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Created Date: 2005-08-08 Completed Date: 2005-12-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0351014 Medline TA: Curr Med Res Opin Country: England |
Other Details:
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Languages: eng Pagination: 1291-5 Citation Subset: IM |
Affiliation:
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Eyesight Associates, Warner Robins, GA, USA. JLGayton@aol.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Aged Cataract Extraction / adverse effects* Female Glucocorticoids / therapeutic use* Humans Inflammation / etiology, prevention & control* Lens Implantation, Intraocular / adverse effects Macular Edema / etiology, prevention & control Male Postoperative Care* Prednisolone / analogs & derivatives*, therapeutic use Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 50-24-8/Prednisolone; 52-21-1/prednisolone acetate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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