| A clinical comparison and long-term follow-up of topical 5-fluorouracil versus laser resurfacing in the treatment of widespread actinic keratoses. | |
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MedLine Citation:
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PMID: 16912977 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND AND OBJECTIVES: Many treatment modalities exist for actinic keratoses (AK). Topical 5-fluorouracil (5-FU) has been one of the standard treatments. Laser resurfacing is a more recent treatment option. In the literature prospective randomized studies comparing these treatments are lacking. STUDY DESIGN/PATIENTS AND METHODS: Prospective randomized study to compare topical 5-FU with Er:YAG laser resurfacing. Fifty-five patients with multiple AK on the scalp and or the face were included. Clinical and histopathological evaluation took place at 3, 6, and 12 months after treatment. RESULTS: At 3, 6, and 12 months after treatment, there were significantly less recurrences in the laser group compared to the group of patients treated with 5-FU. Side effects did occur more frequently in the laser group, especially erythema and hypopigmentation. CONCLUSIONS: Compared to treatment with topical 5-FU, Er:YAG laser resurfacing is more effective regarding recurrence rates. Although significantly more side effects occur, laser resurfacing is a useful therapeutic option especially in patients with widespread AK. |
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Authors:
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Judith U Ostertag; Patricia J F Quaedvlieg; Simone van der Geer; Patty Nelemans; Miranda E M C Christianen; Martino H A M Neumann; Gertruud A M Krekels |
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Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Lasers in surgery and medicine Volume: 38 ISSN: 0196-8092 ISO Abbreviation: Lasers Surg Med Publication Date: 2006 Sep |
Date Detail:
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Created Date: 2006-09-27 Completed Date: 2007-01-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8007168 Medline TA: Lasers Surg Med Country: United States |
Other Details:
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Languages: eng Pagination: 731-9 Citation Subset: IM |
Copyright Information:
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(c) 2006 Wiley-Liss, Inc. |
Affiliation:
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Department of Dermatology, University Hospital Maastricht, Maastricht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Topical Aged Aged, 80 and over Chi-Square Distribution Face Female Fluorouracil / administration & dosage, therapeutic use* Follow-Up Studies Humans Keratosis / drug therapy*, radiotherapy* Laser Therapy, Low-Level / methods* Male Middle Aged Prospective Studies Scalp Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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51-21-8/Fluorouracil |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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