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The clinical characteristics of pulmonary alveolar proteinosis: experience at Seoul National University Hospital, and review of the literature.
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MedLine Citation:
PMID:  10331561     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Pulmonary alveolar proteinosis is such an extremely rare disease in Korea, that only a few cases have been reported. Meanwhile five cases were experienced at Seoul National University Hospital over ten years since 1987. We summarized the clinical characteristics and courses of them. Seven cases reported in the literature were included to add data about clinical characteristics and courses although only a few case reports mentioned patient's course. Middle aged male patients were mainly affected. No association with particular environmental or occupational exposure was identified. Dyspnea on exertion was the main symptom. Bilateral crackles were consistent, and bilateral parahilar hazy infiltrations on plain chest radiograph and ground glass opacity on high-resolution CT were characteristic. Superimposed infection was not identified in any patient at the time of diagnosis. Decreased diffusing capacity and hypoxia were present in almost every case. Whole lung lavage proved to be an effective therapeutic measure. The response to treatment was good. Long-term course of the disease, e.g. recurrence rate, is not yet known.
Authors:
G Kim; S J Lee; H P Lee; C G Yoo; S K Han; Y S Shim; Y W Kim
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Journal of Korean medical science     Volume:  14     ISSN:  1011-8934     ISO Abbreviation:  J. Korean Med. Sci.     Publication Date:  1999 Apr 
Date Detail:
Created Date:  1999-07-19     Completed Date:  1999-07-19     Revised Date:  2011-03-16    
Medline Journal Info:
Nlm Unique ID:  8703518     Medline TA:  J Korean Med Sci     Country:  KOREA (SOUTH)    
Other Details:
Languages:  eng     Pagination:  159-64     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Seoul National University College of Medicine and Lung Institute, SNUMRC, Korea.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Distribution
Aged
Female
Hospitals, Public*
Hospitals, University*
Humans
Korea
Male
Middle Aged
Pulmonary Alveolar Proteinosis / diagnosis,  physiopathology*,  radiography,  therapy
Sex Distribution
Smoking / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): J Korean Med Sci
Journal ID (pmc): jkms
ISSN: 1011-8934
ISSN: 1598-6357
Publisher: Korean Academy of Medical Sciences
Article Information
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Print publication date: Month: 4 Year: 1999
Volume: 14 Issue: 2
First Page: 159 Last Page: 164
ID: 3054359
PubMed Id: 10331561

The clinical characteristics of pulmonary alveolar proteinosis: experience at Seoul National University Hospital, and review of the literature.
G. Kim
S. J. Lee
H. P. Lee
C. G. Yoo
S. K. Han
Y. S. Shim
Y. W. Kim
Department of Internal Medicine, Seoul National University College of Medicine and Lung Institute, SNUMRC, Korea.


Article Categories:
  • Research Article


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