| The clinical and biologic significance of abnormal lipid profiles in patients with myelodysplastic syndromes. | |
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MedLine Citation:
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PMID: 10813538 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Serum lipid profiles were obtained in 108 patients with myelodysplastic syndrome (MDS) and compared to 28 healthy volunteers. Serum cholesterol and low-density and high-density lipoproteins (LDL and HDL) were found to be significantly lower in MDS patients than in normals (p = 0.0001, 0.0038 and 0.037, respectively). This difference was significant for all MDS categories. Serum cholesterol and HDL were negatively related to biopsy cellularity (p = 0.001 and 0.0001, respectively), and serum triglycerides were negatively related to labeling index (p = 0.0003). No differences were noted in the lipid profiles of MDS patients with normal versus abnormal karyotypes. However, low-risk MDS patients with abnormal karyotypes had significantly lower triglyceride levels compared with the high-risk patients (p = 0.027), as did low-risk patients with normal cytogenetics (p = 0.015). Serum HDL levels were significantly higher for the low-risk group with normal cytogenetics as well (p = 0.003). We conclude that serum cholesterol, LDL, and HDL are significantly reduced in MDS patients, probably indicating excessive intracellular lipid biosynthesis in the expanding clone. These relatively simple measurements could serve as important prognostic markers and reliable indicators of disease activity in individual patients. Prospective studies to determine their utility as independent variables that guide the need for active therapeutic intervention are warranted. |
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Authors:
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K Allampallam; D Dutt; C Nair; V Shetty; S Mundle; L Lisak; C Andrews; B Ahmed; L Mazzone; F Zorat; R Borok; M Muzammil; A Gundroo; I Ansaarie; A Raza |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of hematotherapy & stem cell research Volume: 9 ISSN: 1525-8165 ISO Abbreviation: J. Hematother. Stem Cell Res. Publication Date: 2000 Apr |
Date Detail:
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Created Date: 2000-08-21 Completed Date: 2000-08-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100892915 Medline TA: J Hematother Stem Cell Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 247-55 Citation Subset: IM |
Affiliation:
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Rush Cancer Institute, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612-3515, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anemia, Refractory / blood Anemia, Refractory, with Excess of Blasts / blood Anemia, Sideroblastic / blood Apoptosis Cell Division Cholesterol / blood Chromosome Aberrations Cytogenetics Female Humans Leukemia, Myelomonocytic, Chronic / blood Leukocyte Count Lipids / blood*, chemistry Lipoproteins, HDL / blood Lipoproteins, LDL / blood Male Middle Aged Myelodysplastic Syndromes / blood*, genetics Risk Factors Triglycerides / blood Tumor Necrosis Factor-alpha / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P01CA 75606/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 0/Tumor Necrosis Factor-alpha; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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