Document Detail


The clinical and biologic significance of abnormal lipid profiles in patients with myelodysplastic syndromes.
MedLine Citation:
PMID:  10813538     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Serum lipid profiles were obtained in 108 patients with myelodysplastic syndrome (MDS) and compared to 28 healthy volunteers. Serum cholesterol and low-density and high-density lipoproteins (LDL and HDL) were found to be significantly lower in MDS patients than in normals (p = 0.0001, 0.0038 and 0.037, respectively). This difference was significant for all MDS categories. Serum cholesterol and HDL were negatively related to biopsy cellularity (p = 0.001 and 0.0001, respectively), and serum triglycerides were negatively related to labeling index (p = 0.0003). No differences were noted in the lipid profiles of MDS patients with normal versus abnormal karyotypes. However, low-risk MDS patients with abnormal karyotypes had significantly lower triglyceride levels compared with the high-risk patients (p = 0.027), as did low-risk patients with normal cytogenetics (p = 0.015). Serum HDL levels were significantly higher for the low-risk group with normal cytogenetics as well (p = 0.003). We conclude that serum cholesterol, LDL, and HDL are significantly reduced in MDS patients, probably indicating excessive intracellular lipid biosynthesis in the expanding clone. These relatively simple measurements could serve as important prognostic markers and reliable indicators of disease activity in individual patients. Prospective studies to determine their utility as independent variables that guide the need for active therapeutic intervention are warranted.
Authors:
K Allampallam; D Dutt; C Nair; V Shetty; S Mundle; L Lisak; C Andrews; B Ahmed; L Mazzone; F Zorat; R Borok; M Muzammil; A Gundroo; I Ansaarie; A Raza
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of hematotherapy & stem cell research     Volume:  9     ISSN:  1525-8165     ISO Abbreviation:  J. Hematother. Stem Cell Res.     Publication Date:  2000 Apr 
Date Detail:
Created Date:  2000-08-21     Completed Date:  2000-08-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100892915     Medline TA:  J Hematother Stem Cell Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  247-55     Citation Subset:  IM    
Affiliation:
Rush Cancer Institute, Rush-Presbyterian St. Luke's Medical Center, Chicago, IL 60612-3515, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anemia, Refractory / blood
Anemia, Refractory, with Excess of Blasts / blood
Anemia, Sideroblastic / blood
Apoptosis
Cell Division
Cholesterol / blood
Chromosome Aberrations
Cytogenetics
Female
Humans
Leukemia, Myelomonocytic, Chronic / blood
Leukocyte Count
Lipids / blood*,  chemistry
Lipoproteins, HDL / blood
Lipoproteins, LDL / blood
Male
Middle Aged
Myelodysplastic Syndromes / blood*,  genetics
Risk Factors
Triglycerides / blood
Tumor Necrosis Factor-alpha / metabolism
Grant Support
ID/Acronym/Agency:
P01CA 75606/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
0/Lipids; 0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Triglycerides; 0/Tumor Necrosis Factor-alpha; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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