| The clinical benefits of tenofovir for simian immunodeficiency virus-infected macaques are larger than predicted by its effects on standard viral and immunologic parameters. | |
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MedLine Citation:
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PMID: 15220696 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previous studies have demonstrated that tenofovir (9-[2-(phosphonomethoxy)propyl]adenine; PMPA) treatment is usually very effective in suppressing viremia in macaques infected with simian immunodeficiency virus (SIV). The present study focuses on a subset of infant macaques that were chronically infected with highly virulent SIVmac251, and for which prolonged tenofovir treatment failed to significantly suppress viral RNA levels in plasma despite the presence of tenofovirsusceptible virus at the onset of therapy. While untreated animals with similarly high viremia developed fatal immunodeficiency within 3-6 months, these tenofovir-treated animals had significantly improved survival (up to 3.5 years). This clinical benefit occurred even in animals for which tenofovir had little or no effect on CD4 and CD8 lymphocyte counts and antibody responses to SIV and test antigens. Thus, the clinical benefits of tenofovir were larger than predicted by plasma viral RNA levels and other routine laboratory parameters. |
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Authors:
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Koen K A Van Rompay; Raman P Singh; Laurie L Brignolo; Jonathan R Lawson; Kimberli A Schmidt; Bapi Pahar; Don R Canfield; Ross P Tarara; Donald L Sodora; Norbert Bischofberger; Marta L Marthas |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Journal of acquired immune deficiency syndromes (1999) Volume: 36 ISSN: 1525-4135 ISO Abbreviation: J. Acquir. Immune Defic. Syndr. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-06-28 Completed Date: 2005-09-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100892005 Medline TA: J Acquir Immune Defic Syndr Country: United States |
Other Details:
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Languages: eng Pagination: 900-14 Citation Subset: IM; X |
Affiliation:
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The California National Primate Research Center, Davis, 95616, USA. kkvanrompay@ucdavis.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenine
/
administration & dosage,
analogs & derivatives*,
therapeutic use Animals Animals, Newborn Anti-HIV Agents / administration & dosage, therapeutic use* Antibodies, Viral / blood CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Chronic Disease Drug Evaluation, Preclinical Female Injections, Subcutaneous Lymphocyte Count Macaca mulatta Male Phosphonic Acids / administration & dosage, therapeutic use* Simian Acquired Immunodeficiency Syndrome / blood, drug therapy*, immunology, virology Simian immunodeficiency virus* / immunology Survival Analysis Viral Load |
| Grant Support | |
ID/Acronym/Agency:
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DE12926/DE/NIDCR NIH HHS; R01 AI46320-01/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-HIV Agents; 0/Antibodies, Viral; 0/Phosphonic Acids; 107021-12-5/tenofovir; 73-24-5/Adenine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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