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The clinical availability of non-alcoholic fatty liver disease as an early predictor of type 2 diabetes mellitus in korean men: 5-years' prospective cohort study.
MedLine Citation:
PMID:  23213066     Owner:  NLM     Status:  Publisher    
There have been several reports about clinical association between type 2 diabetes mellitus (DM) and non-alcoholic fatty liver disease (NAFLD). However, most of studies were about the unilateral effects of type 2 DM on NAFLD, and studies for the reverse relation were rare. Thus, this study was designed to investigate the effect of NAFLD on the type 2 DM. We conducted a prospective cohort study on the 25,232 Korean men without type 2 DM for 5 years. We serially checked the various metabolic factors including fasting glucose and hemoglobin A1c (HbA1c), and monitored the development of type 2 DM. Incidence rate of type 2 DM was compared according to the degree of NAFLD (normal, mild, and moderate to severe), and Cox proportional hazards model was used to measure the hazard ratios (HRs) of NAFLD on type 2 DM. The incidence rate of type 2 DM increased according to the degree of NAFLD (normal: 7.0%, mild: 9.8%, moderate to severe: 17.8 %, P < 0.001). Even after adjusting for other multiple covariates, the HRs (95% CI) for type 2 DM development was higher in mild group (1.09; 0.81-1.48) and moderate to severe group (1.73; 1.00-3.01) compared to normal group, respectively (P for trend <0.001). In conclusion, the development of type 2 DM is more potentially associated with more progressive NAFLD than normal or milder state. In addition, NAFLD was an independent risk factor of future development of type 2 DM. These results suggest the potential availability of NAFLD as an early predictor of type 2 DM. (HEPATOLOGY 2012.).
Sung Keun Park; Mi Hae Seo; Ho Cheol Shin; Jae-Hong Ryoo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-5
Journal Detail:
Title:  Hepatology (Baltimore, Md.)     Volume:  -     ISSN:  1527-3350     ISO Abbreviation:  Hepatology     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8302946     Medline TA:  Hepatology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 American Association for the Study of Liver Diseases.
Total healthcare center, Kangbuk Samsung Hospital, Sungkyunkwan University, School of medicine, Seoul, Korea.
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