Document Detail


The clinical application value of PET/CT in adenocarcinoma with bronchioloalveolar carcinoma features.
MedLine Citation:
PMID:  20614257     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: The goal of our study was to demonstrate the clinical usefulness of positron emission tomography/computed tomography (PET/CT) for adenocarcinoma with bronchioloalveolar carcinoma (BAC) features, through evaluating the relationship between the intrathoracic lymph node metastases and maximum standardized uptake value (SUVmax), tumor size of the primary tumor and the ratio of BAC component and analysing the correlation of SUVmax, tumor size and the ratio of BAC component.
METHODS: This was a retrospective study. Forty-five patients with focal peripheral lung adenocarcinoma with BAC features were included in this study and underwent the PET/CT scan. Twenty-one patients were women and 24 were men. None of the patients had insulin-dependent diabetes and the serum glucose levels in all patients just before (18)F-FDG was injected were less than 120 mg/dl. The diagnosis of the lesion was made by surgical histopathology.
RESULTS: All patients underwent successful surgery, and pathologic examination confirmed that 34 of 118 excised nodal groups in 18 patients were proved to be positive for malignancy. Univariate analysis revealed 3 potential factors related to intrathoracic lymph node metastases: SUVmax (P = 0.002); the ratio of BAC component (P = 0.002); maximum dimension of a tumor on mediastinal window setting images (mDmax, P = 0.025). The maximum dimension of a tumor on pulmonary window setting images (pDmax, P = 0.373) had no significance. A receiver operating characteristic (ROC) curve based on SUVmax, mDmax and the ratio of BAC component was constructed, the area under curve (AUC) was 85.2, 70.3 and 81.5% separately. There was no statistical significance between AUC of SUVmax and AUC of the ratio of BAC component (Z = 0.901, P = 0.368). The AUC of SUVmax and AUC of the ratio of BAC component were significantly higher than AUC of mDmax (Z = 2.112, P = 0.035; Z = 2.016, P = 0.042).The SUVmax and the ratio of BAC component had significant inverse correlation (r = -0.85, P < 0.01). The mDmax and the ratio of BAC component had significant inverse correlation (r = -0.69, P < 0.01). The SUVmax and mDmax had significant correlation (r = 0.60, P < 0.01).
CONCLUSIONS: PET/CT would be clinically useful for adenocarcinoma with BAC features, because SUVmax obtained by PET/CT can predict the incidence of intrathoracic lymph node metastases at preoperative stages and even for inoperable patients.
Authors:
Songtao Liu; Hongxia Cheng; Shuzhan Yao; Caixia Wang; Guangxiu Han; Xin Li; Cheng Liu
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Publication Detail:
Type:  Journal Article     Date:  2010-07-08
Journal Detail:
Title:  Annals of nuclear medicine     Volume:  24     ISSN:  1864-6433     ISO Abbreviation:  Ann Nucl Med     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-18     Completed Date:  2010-12-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913398     Medline TA:  Ann Nucl Med     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  541-7     Citation Subset:  IM    
Affiliation:
Department of PET/CT Center, Provincial Hospital, Shandong University, Jinan, People's Republic of China.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / complications*,  diagnosis*,  pathology
Adenocarcinoma, Bronchiolo-Alveolar / complications*
Female
Humans
Lymphatic Metastasis
Male
Middle Aged
Positron-Emission Tomography*
ROC Curve
Retrospective Studies
Tomography, X-Ray Computed*
Tumor Burden

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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