Document Detail

The clinical application of cryoplasty for infrainguinal peripheral arterial disease.
MedLine Citation:
PMID:  16849095     Owner:  NLM     Status:  MEDLINE    
Interventional outcomes for peripheral arterial disease of the lower extremity have long suffered from suboptimal patency rates. Many drugs and devices have been studied in an attempt to alter the aggressive neointimal response witnessed in infra-inguinal vessels with little success. Cryoplasty, a recent entrant into the endovascular arena, combines the time-tested mechanics of percutaneous transluminal angioplasty with the biologically favorable effects of cryotherapy. Cryoplasty specifically targets infra-inguinal lesions and minimizes neointimal proliferation via induction of apoptosis in the cell lines that contribute to restenosis. In addition, the mechanistic effects on the architecture of the vessel wall and the plaque itself have been found to reduce the likelihood of significant dissection following cryoplasty as compared with those expected with percutaneous transluminal angioplasty. Several clinical trials have demonstrated the efficacy of cryoplasty in patients with superficial femoral and popliteal arterial disease, as well as in critical limb ischemia patients with tibioperoneal arterial disease. Current clinical applications in the lower extremity will be reviewed along with technical tips for device use and opportunities for device synergy with other existing technologies.
James D Joye
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Techniques in vascular and interventional radiology     Volume:  8     ISSN:  1089-2516     ISO Abbreviation:  Tech Vasc Interv Radiol     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2006-07-19     Completed Date:  2006-12-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806675     Medline TA:  Tech Vasc Interv Radiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  160-4     Citation Subset:  IM    
El Camino Hospital, Mountain View, CA, USA.
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MeSH Terms
Angioplasty, Balloon / methods*
Arterial Occlusive Diseases / radiography,  therapy*
Cryotherapy / methods*
Femoral Artery* / radiography
Leg / blood supply*
Peripheral Vascular Diseases / radiography,  therapy*
Popliteal Artery* / radiography
Vascular Patency

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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