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A clinical analysis of nine new pediatric and adolescent cases of benign minor salivary gland neoplasms and a review of the literature.
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PMID:  22967947     Owner:  NLM     Status:  PubMed-not-MEDLINE    
INTRODUCTION: Minor salivary gland neoplasms of epithelial origin are rare in children and adolescents and most are not well documented, except for a few small series and case reports. This study represents a retrospective clinical analysis of nine cases of benign epithelial salivary gland neoplasms accessioned over a 35-year period at the Louisiana State University School of Dentistry and combines the data with well-documented cases from the English-language literature.
METHODS: A retrospective clinical analysis of nine cases of benign epithelial salivary gland neoplasms was performed over a 35-year period at the Louisiana State University School of Dentistry and combined with data of well-documented cases from the English-language literature.
RESULTS: The nine benign salivary gland neoplasms in patients aged 19 months to 18 years accounted for 2.3% of the Louisiana State University School of Dentistry accessioned salivary gland tumors. These nine cases comprised eight pleomorphic adenomas and one cystadenoma. There were 40 cases in the literature, of which 34 were pleomorphic adenomas. Combining the data for the 42 pleomorphic adenomas resulted in a mean age of 12 years with a 2.8:1 female predilection. The hard palate and/or soft palate were the most common site (69.1%). The average duration and size was 2.1 years and 2.4cm, respectively. Bone involvement occurred in seven cases. Wide local excision was the treatment most often employed. Cases followed for two years or more had a recurrence rate of 13.0%. The remaining seven neoplasms in the combined data comprised myoepithelioma, cystadenoma and sialadenoma papilliferum.
CONCLUSIONS: A relatively long duration (2 years) of a submucosal mass in a minor salivary gland-bearing area with or without bone involvement occurring in a child or adolescent should raise the question of a possible salivary gland neoplasm. A pleomorphic adenoma is the most common benign salivary gland neoplasm in the first and second decade of life. Complete surgical excision affords the best chance of preventing recurrence for pleomorphic adenomas. The recurrence rate of pleomorphic adenomas with two or more years follow-up is 13.0%. Other types of minor salivary gland neoplasms are exceedingly rare and therefore data is sparse, precluding any valid conclusions.
Priyanshi Ritwik; Robert B Brannon
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Publication Detail:
Type:  Journal Article     Date:  2012-09-11
Journal Detail:
Title:  Journal of medical case reports     Volume:  6     ISSN:  1752-1947     ISO Abbreviation:  J Med Case Rep     Publication Date:  2012  
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Created Date:  2012-11-01     Completed Date:  2012-11-02     Revised Date:  2014-07-14    
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Nlm Unique ID:  101293382     Medline TA:  J Med Case Rep     Country:  England    
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Languages:  eng     Pagination:  287     Citation Subset:  -    
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Journal ID (nlm-ta): J Med Case Rep
Journal ID (iso-abbrev): J Med Case Rep
ISSN: 1752-1947
Publisher: BioMed Central
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Copyright ©2012 Ritwik and Brannon; licensee BioMed Central Ltd.
Received Day: 24 Month: 10 Year: 2011
Accepted Day: 2 Month: 3 Year: 2012
collection publication date: Year: 2012
Electronic publication date: Day: 11 Month: 9 Year: 2012
Volume: 6First Page: 287 Last Page: 287
PubMed Id: 22967947
ID: 3485090
Publisher Id: 1752-1947-6-287
DOI: 10.1186/1752-1947-6-287

A clinical analysis of nine new pediatric and adolescent cases of benign minor salivary gland neoplasms and a review of the literature
Priyanshi Ritwik1 Email:
Robert B Brannon2 Email:
1Department of Pediatric Dentistry, LSU School of Dentistry, 1100 Florida Avenue, New Orleans, LA, 70119, USA
2Division of Oral and Maxillofacial Pathology, LSU School of Dentistry, 1100 Florida Avenue, New Orleans, LA, 70119, USA


Only 3% to5% of all salivary gland neoplasms occur in children and adolescents [1,2]. Two types of neoplasms are found in the salivary glands of pediatric age group patients: neoplasms of epithelial or parenchymal origin and neoplasms of mesenchymal or interstitial origin. The vast majority of the mesenchymal neoplasms occurring in the parotid gland are vasoformative, that is, hemangiomas [1], while the most common types of salivary gland neoplasms of epithelial (parenchymal) origin are pleomorphic adenomas and mucoepidermoid carcinomas.

Most of these epithelial neoplasms are found in the parotid gland; only a limited number of cases occurring in the minor glands of children and adolescents have been well-documented [2]. In fact, a review of the literature revealed only 40 well-documented cases of benign minor salivary gland tumors in this age group [3-28]. Therefore, the purpose of this retrospective analysis was to investigate the clinical features and biologic behavior of a series of benign epithelial minor salivary gland neoplasms occurring in children and adolescents, aged 19 months to 18 years.

Case presentation

A total of nine benign minor salivary gland neoplasms were found in patients aged below 19 years out of a total of 396 minor salivary gland neoplasms accessioned over a 35-year period. This is a prevalence of 2.3% in the Louisiana State University School of Dentistry (LSUSD) material. The neoplasms consisted of eight pleomorphic adenomas (PA) and one cystadenoma.

Summary of findings

A search of the English-language literature revealed 34 PAs [3-23], four myoepitheliomas [25-28], one cystadenoma [7], and one sialadenoma papilliferum [24]. PAs were found to be by far the most commonly occurring benign lesions of minor salivary glands in this age group. A summary of the demographics, clinical findings, treatment and follow-up of the well-documented benign minor salivary gland neoplasms in the literature, in addition to the nine new cases from LSUSD, is shown in Additional file 1: Tables S1 and S2, for a total of 49 cases.

Pleomorphic adenomas

Data for the combined 42 PAs are in Additional file 1: Table S1. The age range was 19 months to 18 years, with a mean of 12 years; 35.7% of the tumors occurred in patients 10 years of age or younger. There was a marked peak in incidence at age 12 years and then again in the later teenage years (Figure 1). The female-to-male ratio was calculated to be 2.8:1. Race was not stated for 21 patients (50%); for the cases reporting race there was essentially an equal distribution between black and white patients. Of the 42 neoplasms, 29 (69.1%) occurred in the minor salivary glands of the hard and/or soft palate, six (14.3%) in the upper lip, four (9.5%) in the buccal mucosa, and three (7.1%) in the tongue. Seven of the palatal neoplasms caused pressure erosion, a smooth depression, or perforation of the under lying bone. One of these palatal neoplasms perforated the palatal bone and extended into the nasal cavity. The majority of PAs were painless, firm submucosal masses or nodules ranging in size from 0.5cm to 5.0cm with a mean of 2.4cm. Sixteen of the 42 cases had reliable patient history reporting a 2.1 year duration of the tumor before definitive diagnosis.

Twenty-four cases with follow-up information of at least 2 years were treated by local surgical excision. Follow-up ranged from 2 to 39 years (mean 9.2 years). Recurrences were reported in three cases for a recurrence rate of 13.0%. The three recurrent cases were all on the hard palate and recurred 2 years, 3 years, and 5 years after the initial surgery.

Other lesions

Data for the two cystadenomas, one sialadenoma papilliferum and the four myoepitheliomas are presented in Additional file 1: Table S2.


We attempted to outline the clinical features and biologic behavior of benign neoplasms arising from minor salivary glands in children and adolescents. It is acknowledged that there are limitations to the interpretation of data from a retrospective study such as this. For example, the clinical findings and other pertinent information recorded on submitted pathology request forms are unfortunately highly variable and often lack complete information and the same is true for reported cases.

While more pediatric cases have been reported cumulatively in other published salivary gland series, any correlation between patient-specific details and the clinical lesion cannot be made. The approach of our study limits the number of accepted cases, but yields more clinically relevant information. The patients in the LSUSD series were only from the state of Louisiana, thus representing patients from a single geographic area and a single institution experience. The cases accepted from the literature review represent a more global pediatric population, including Hispanic and Asian children, who were not represented in our LSUSD series. Since the socioeconomic status of the children was not known in our study, the association of socioeconomic status to the incidence as well as prognosis of the lesions could not be explored.

Epithelial neoplasms originating in the minor salivary glands account for approximately 15% of all salivary gland neoplasms [29,30]. In the current LSUSD series, 2.3% of the benign epithelial minor salivary gland neoplasms occurred in patients below 19 years of age, which is in close agreement with the series of Waldron et al. and Kusama et al. who found an incidence of 3.1% and 4.6%, respectively [30,31].

A PA is composed of a wide spectrum of epithelial and mesenchymal tissue derived from cells with ductal and myoepithelial features and it is by far the most common salivary gland neoplasm in children [1,32]. Although it is commonly stated that neoplasms of minor salivary glands rarely occur prior to the second decade [33], we found that, when combining the well-documented literature cases with our LSUSD cases, 28.6% of PAs arising from minor salivary glands in children occurred during the first decade of life. Cumulative data assessment revealed a female gender predilection of 2.8:1 and a predilection for the hard and/or soft palate (69.1%).

Information regarding the biologic behavior of minor salivary gland PAs in children and adolescents is, in general, underprovided. The risk of recurrence of PAs has been speculated to be lower if arising from the minor salivary glands rather than the major glands [34]. In fact, Chau and Radden reported follow-up on 27 intra-oral PAs in patients over a wide age range (second to eighth decade) treated by excisional biopsy and found no recurrences (mean follow-up period 5.3 years), including in two neoplasms which were incompletely excised and two where the tumor extended to the surgical margins [35]. Additionally, Budnick reported a PA in the upper lip of a 17-year-old black woman which was incompletely excised and had no evidence of recurrence on 3 years of follow-up [7]. The recurrence rate of PAs in minor salivary glands of children in our study was 13.0%, which is of clinical significance. This recurrence rate was recorded from 24 well-documented pediatric and adolescent PAs with an average follow-up duration of 9.2 years. The three recurrent PAs involved the hard palate, with one causing bone resorption, one with no bone involvement [19] and one case did not state if there was bone involvement [3]. The assessment for possible causes of recurrence in the three cases varied. The size of the lesion was recorded in two of the three recurrent cases; both were 2.0cm or less in diameter. With regards the surgical margins of these recurrent cases, Byars et al. [3] did not comment on the state of the surgical margins, Shaaban et al. [19] reported the surgical margins in the definitive excision were free of tumor and, in the LSUSD case, the margins could not be definitively determined as treatment consisted of tumor excision with curettage of the involved palatal bone, making assessment difficult to evaluate with certainty.

In the cases with no recurrence, the surgical margins were not described with any degree of certainty, making it impossible to adequately explore margin involvement as an absolute predictor of recurrence. However, in four of the newly reported LSUSD cases with follow-up of 8 months, 5 years, 8 years and 24 years, the surgical margins were free of tumor. Of those, the case that was followed for 5 years had a focus of tumor in the capsule, but did not recur.

A myoepithelioma is a benign tumor composed of various proportions of plasmacytoid, spindle, epithelioid, and clear cells that exhibit myoepithelial differentiation and generally lack ductal differentiation [36]. While some investigators consider it to be a distinct entity, others believe that it represents one end of the spectrum of the PA and is therefore a variant of PA [27,36]. Regardless of its specific classification, it possesses a similar if not identical biologic behavior to a PA [36]. There are too few cases reported to define its characteristics in the first and second decade of life. However, based on four cases, it does appear to possess similar clinical characteristics and biologic behavior to a PA ( Additional file 1: Table S2).

Minor salivary gland cystadenomas are rare benign well-circumscribed tumors composed of cystic and papillary structures lined with cuboidal or columnar ductal epithelium that appears benign on histology [30]. The average age of incidence is 57 years; they are exceedingly rare below the age of 20 years. The youngest patient reported to have a cystadenoma was 12 years old [7]. Lastly, a sialadenoma papilliferum is a benign exophytic papillary tumor arising from the salivary gland duct. It too is rare below the age of 20 years with only one case reported, in the upper lip of an 18-year-old man [24].

Although minor salivary gland tumors are decidedly uncommon in the first two decades of life, they should be considered in the clinical differential diagnosis for any submucosal nodule or mass in a salivary gland-bearing area. In this study, the average duration of 16 PAs with reliable historical information was 2.1 years before definitive diagnosis. As with any benign or malignant tumor, early definitive diagnosis and appropriate treatment afford a better chance for a cure. This is especially important for minor salivary gland tumors because a high percentage are malignant [1,2].


The following may be concluded from the results of this study regarding benign epithelial (parenchymal) minor salivary gland tumors in children and adolescents (ages 19 months to 18 years):

1. The prevalence of benign epithelial minor salivary gland tumors in the LSUSD series was 2.3%.

2. Minor salivary gland tumors are more common in female patients.

3. Minor salivary gland tumors have a high predilection for the hard and/or soft palate and have been well-documented in lesser numbers in the upper lip, buccal mucosa, and tongue.

4. Minor salivary gland tumors involving the hard palate may resorb underlying bone.

5. The long duration of a painless submucosal mass in a salivary gland-bearing area does not preclude a minor salivary gland neoplasm.

6. The recurrence rate of minor salivary gland PAs in the first two decades of life is low (13.0%) based on this review of 24 well-documented cases with two or more years follow-up.

7. Complete surgical excision is the most important factor in preventing recurrence of a benign minor salivary gland neoplasm.

8. Long-term clinical follow-up of at least 5 years and the possibility of recurrence should be discussed with the patient and parents when benign minor salivary gland tumors are diagnosed in pediatric and adolescent patients.


The archived oral pathology cases from the LSUSD Division of Oral and Maxillofacial Pathology diagnosed as benign salivary gland tumors from January 1 1969 to December 31 2004 were reviewed and patients aged below 19 years with any type of intra-oral benign minor salivary gland neoplasm were selected. The search focused on all types of benign minor salivary gland neoplasms in this age group. All cases consisted of hematoxylin and eosin-stained microscopic slides and the accompanying pathology request form. No cases were rejected for lack of detailed clinical or treatment information. There were no missing specimens or reports in the LSUSD archives. All of the cases in this study were submitted by oral and maxillofacial surgeons in private practice in the state of Louisiana with the exception of one case, which was from the LSUSD Department of Oral and Maxillofacial Surgery. The Louisiana State University Health Sciences Center Institutional Review Board (LSUHSC IRB) approved the research protocol (IRB #6450). Demographic, clinical, and treatment information was recorded for each patient. All of the microscopic diagnoses were made by American Board of Oral and Maxillofacial Pathology-certified pathologists. Additionally, the microscopic diagnosis of each case was reviewed and verified by one of the authors (RBB), an American Board of Oral and Maxillofacial Pathology-certified pathologist, using the diagnostic criteria for PAs and cystadenomas set forth by Ellis and Auclair [36]. A search was performed of the English-language medical and dental literature for well-documented minor salivary gland neoplasms in the pediatric and adolescent age group. It should be noted that, although numerous investigators have published series of salivary gland neoplasms, they provide an age range only and do not correlate the age of the patient to the location of the lesion or offer other demographic and clinical information. Some of these series did indicate that at least one patient was in the first or second decade of life; however, we did not include them in this study because they lacked the adequate detail we required.


This study was approved by the LSUHSC IRB (#6450), which oversees and approves all research projects conducted on humans, and also ensures that all research conducted meets ethical standards. The IRB approval obtained for this research project exempted obtaining individual consents from each of the patients on the grounds that it would be virtually impossible to get meaningful data in a retrospective study such as this if authorization is required; some of the pathology reports are up to 20 years old, dentists have lost contact with patients, and dentists periodically purge records, destroying all contact data. The research could not be practically conducted if a consent from each individual patient was required.

Competing interests

The authors declare that they have no competing interests.

Authors’ contributions

PR and RBB reviewed the clinical and histopatholgic data from the selected cases and the literature, and analyzed the data. RBB reviewed histopathologic microslides and confirmed the diagnosis for the cases from the LSUSD series. Both authors read and approved the final manuscript.

Supplementary Material Additional file 1

Table S1. Pleomorphic adenoma. Tabulation of patient demographics, lesion site, duration, bone involvement, treatment and follow-up information for pleomorphic adenoma. Table S2. Benign salivary gland tumors (non-PA type). Tabulation of patient demographics, lesion site, duration, bone involvement, treatment and follow-up information for cystadenoma, sialadenoma papilliferum, myoepithelioma, myoepithelioma plasmacytoid variant.

Click here for additional data file (1752-1947-6-287-S1.doc)


We wish to acknowledge Elizabeth Strother from the LSUSD and, associate director for dental library services, for her assistance in the preparation of this article.

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[Figure ID: F1]
Figure 1 

Age distribution of patients with pleomorphic adenoma arising from minor salivary glands

Article Categories:
  • Research Article

Keywords: Benign tumors, Minor salivary gland, Benign tumors, Pediatric.

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