Document Detail

The clever fetus: responding to inflammation to minimize lung injury.
MedLine Citation:
PMID:  16210842     Owner:  NLM     Status:  MEDLINE    
Clinical and experimental information indicate that fetal exposure to inflammation can induce lung maturation. This inflammation may be chronic and indolent. We present clinical and experimental information that challenge assumptions about chorioamnionitis associated infection/inflammatory exposures to the fetus. We question the assumption that the fetal compartment is sterile, and that delivery is inevitable if chronic infection/inflammation is present. We demonstrate that the preterm fetus can develop a brisk and adequate inflammatory response, and the fetus also can quickly modulate and downregulate inflammation to prevent injury. The fetus at risk of early preterm delivery may be exposed to both chorioamnionitis and glucocorticoids. Both exposures can either increase or decrease fetal inflammatory responses depending on the timing of the exposures. The immunomodulatory ability of the fetus to fetal exposures remains an unexplored research field.
Boris W Kramer; Alan H Jobe
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Biology of the neonate     Volume:  88     ISSN:  0006-3126     ISO Abbreviation:  Biol. Neonate     Publication Date:  2005  
Date Detail:
Created Date:  2005-10-07     Completed Date:  2005-11-08     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0247551     Medline TA:  Biol Neonate     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  202-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2005 S. Karger AG, Basel.
Universitäts-Kinderklinik, Würzburg, Germany.
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MeSH Terms
Bacterial Infections / complications
Fetal Diseases / physiopathology*
Fetal Organ Maturity
Fetus / physiology*
Inflammation / microbiology,  physiopathology*
Lung / embryology*
Obstetric Labor, Premature / etiology
Grant Support

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