Document Detail

The clearance of oral high-risk hpv infection is impaired by long-term persistence of cervical hpv infection.
MedLine Citation:
PMID:  24890849     Owner:  NLM     Status:  Publisher    
Persistence of high-risk (HR) human papillomavirus (HPV) infection of the uterine cervix increases the risk of cervical cancer. Oral HPV infections are among potential covariates of long-term genotype-specific persistent cervical HR-HPV infections. It is not known whether this persistence reflects inability of the host to reject HPV infections in general. A case-control setting was designed to estimate the covariates of long-term persistent cervical HR-HPV infections using multivariate GEE-models. HPV was detected with PCR using GP05+/GP06+-primers and genotyped for 24 HPVs with Multimetrix-kit. The cases (n=43) included women who had genotype-specific persistent cervical HR-HPV-infection for at least 24 months (24M+) and controls were women who tested repeatedly HPV-negative in their cervical samples (n=52). These women represent a sub-cohort of the Finnish Family HPV Study. The cases differed significantly from the HPV-negative controls in several aspects: they were younger, had a longer mean time to incident oral HPV infection (40.7mo vs 23.6mo), longer duration of oral HPV persistence (38.4mo vs 14.1mo), and longer time to clearance of their oral HPV infection (50.0mo vs 28.2mo). In multivariate GEE-analysis, the 2(nd) pregnancy during the FU was the only independent predictor with significant protective effect against 24M+ persistent cervical HR-HPV-infections, OR of 0.15 (95% CI 0.07-0.34). To conclude, long-term persistent cervical HR-HPV-infections are associated with a prolonged clearance of oral HR-HPV-infections while new pregnancy protects against persistent cervical HR-HPV-infections. This article is protected by copyright. All rights reserved.
Karolina Louvanto; Jaana Rautava; Kari Syrjänen; Seija Grénman; Stina Syrjänen
Related Documents :
25124689 - Matrix metalloproteinase (mmp) -2 and -9 as inflammation markers of trichinella spirali...
23334179 - A novel bioluminescence mouse model for monitoring oropharyngeal candidiasis in mice.
23029589 - Bladder morbidity and hepatic fibrosis in mixed schistosoma haematobium and s. mansoni ...
24383909 - Reactive arthritis after pharyngeal infection: report of two siblings.
23307379 - Association between movement and sin nombre virus (bunyaviridae: hantavirus) infection ...
23920409 - Host immune responses of ducks infected with h5n1 highly pathogenic avian influenza vir...
25037559 - Current concepts in the surgical management of acute the diabetic foot infections.
19014339 - Differential expression of the type i interferon pathway during persistent and transien...
6541839 - Experimental infection of sheep by the camel stomach worm, haemonchus longistipes.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-30
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  -     ISSN:  1469-0691     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Next Document:  Cardiac Implantable Electronic Device Removal in Patients with Left Ventricular Assist Device Associ...