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The clearance of oral high-risk hpv infection is impaired by long-term persistence of cervical hpv infection.
MedLine Citation:
PMID:  24890849     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Persistence of high-risk (HR) human papillomavirus (HPV) infection of the uterine cervix increases the risk of cervical cancer. Oral HPV infections are among potential covariates of long-term genotype-specific persistent cervical HR-HPV infections. It is not known whether this persistence reflects inability of the host to reject HPV infections in general. A case-control setting was designed to estimate the covariates of long-term persistent cervical HR-HPV infections using multivariate GEE-models. HPV was detected with PCR using GP05+/GP06+-primers and genotyped for 24 HPVs with Multimetrix-kit. The cases (n=43) included women who had genotype-specific persistent cervical HR-HPV-infection for at least 24 months (24M+) and controls were women who tested repeatedly HPV-negative in their cervical samples (n=52). These women represent a sub-cohort of the Finnish Family HPV Study. The cases differed significantly from the HPV-negative controls in several aspects: they were younger, had a longer mean time to incident oral HPV infection (40.7mo vs 23.6mo), longer duration of oral HPV persistence (38.4mo vs 14.1mo), and longer time to clearance of their oral HPV infection (50.0mo vs 28.2mo). In multivariate GEE-analysis, the 2(nd) pregnancy during the FU was the only independent predictor with significant protective effect against 24M+ persistent cervical HR-HPV-infections, OR of 0.15 (95% CI 0.07-0.34). To conclude, long-term persistent cervical HR-HPV-infections are associated with a prolonged clearance of oral HR-HPV-infections while new pregnancy protects against persistent cervical HR-HPV-infections. This article is protected by copyright. All rights reserved.
Authors:
Karolina Louvanto; Jaana Rautava; Kari Syrjänen; Seija Grénman; Stina Syrjänen
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-30
Journal Detail:
Title:  Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases     Volume:  -     ISSN:  1469-0691     ISO Abbreviation:  Clin. Microbiol. Infect.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9516420     Medline TA:  Clin Microbiol Infect     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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