Document Detail

The classification and treatment of antibody-mediated renal allograft injury: where do we stand?
MedLine Citation:
PMID:  17167504     Owner:  NLM     Status:  MEDLINE    
Since the acceptance of the detection of C4d in allografts as a reliable tool to mark a humoral alloresponse, de novo antibody-induced graft injury has attracted much attention. Antibodies and B cells are the new frontier in transplantation. At this juncture carefully designed studies are critical in order to gain solid diagnostic, therapeutic, and prognostic knowledge about the role of antibodies in graft injury and to avoid any confusion and misconception. One prerequisite is the strict adherence to refined classification systems of renal transplant rejection that carefully split and categorize different phenotypes of humoral mediated graft damage and ideally also include information on anti-donor antibody specificity and titers. Sun and colleagues follow this concept and provide evidence that mixed cellular and antibody-mediated graft rejection can respond favorably to intensified immunosuppression with tacrolimus and mycophenolate mofetil. What will the future bring to treat rejection episodes with a dominant, co-dominant, or minor antibody response?
V Nickeleit; K Andreoni
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Publication Detail:
Type:  Comment; Journal Article; Review    
Journal Detail:
Title:  Kidney international     Volume:  71     ISSN:  0085-2538     ISO Abbreviation:  Kidney Int.     Publication Date:  2007 Jan 
Date Detail:
Created Date:  2006-12-14     Completed Date:  2007-03-07     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0323470     Medline TA:  Kidney Int     Country:  United States    
Other Details:
Languages:  eng     Pagination:  7-11     Citation Subset:  IM    
Department of Pathology, Nephropathology Laboratory, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7525, USA.
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MeSH Terms
Graft Rejection / classification,  etiology,  pathology,  therapy
Immunity, Cellular
Isoantibodies / biosynthesis
Kidney Transplantation / adverse effects*,  immunology,  pathology
Tissue Donors
Reg. No./Substance:
Comment On:
Kidney Int. 2007 Jan;71(1):24-30   [PMID:  16969384 ]

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