Document Detail


The classification, functions and clinical use of different isoforms of HCG.
MedLine Citation:
PMID:  16877746     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
HCG is composed of two subunits, HCGalpha and HCGbeta. During early pregnancy, HCG stimulates progesterone production in the corpus luteum, and injection of HCG is widely used to induce ovulation in assisted reproduction treatment (ART). Under experimental conditions, the free subunits have been shown to exert functions other than those of HCG, but the relevance of these remains to be determined. Intact HCG, free subunits and degraded forms of these occur in biological fluids, and determinations of these are important for diagnosis and monitoring of pregnancy, pregnancy-related disorders and several types of cancer. Development of optimal methods for the various forms has been hampered by lack of appropriate standards and expression of the concentrations of the various forms in units that are not comparable. Furthermore, the nomenclature for HCG assays is confusing and in some cases misleading. These problems can now be solved; a uniform nomenclature has been established, and new standards are available for HCG, its subunits HCGalpha and HCGbeta, the partially degraded or nicked forms of HCG and HCGbeta, and the beta-core fragment. This review describes the biochemical and biological background for the clinical use of determinations of various forms of HCG. The clinical use of HCG and studies on HCG vaccines are briefly reviewed.
Authors:
Ulf-Håkan Stenman; Aila Tiitinen; Henrik Alfthan; Leena Valmu
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-07-28
Journal Detail:
Title:  Human reproduction update     Volume:  12     ISSN:  1355-4786     ISO Abbreviation:  Hum. Reprod. Update     Publication Date:    2006 Nov-Dec
Date Detail:
Created Date:  2006-10-18     Completed Date:  2006-12-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9507614     Medline TA:  Hum Reprod Update     Country:  England    
Other Details:
Languages:  eng     Pagination:  769-84     Citation Subset:  IM    
Affiliation:
Department of Clinical Chemistry, Helsinki University Central Hospital, Helsinki, Finland. ulf-hakan.stenman@hus.fi
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MeSH Terms
Descriptor/Qualifier:
Chorionic Gonadotropin / analysis,  classification,  physiology*,  therapeutic use*
Epitopes
Female
Gestational Trophoblastic Neoplasms / diagnosis
Humans
Multigene Family
Ovulation Induction / methods
Pregnancy
Pregnancy Tests
Protein Isoforms
Radioimmunoassay
Recombinant Proteins / therapeutic use
Reference Standards
Reference Values
Sensitivity and Specificity
Uterine Neoplasms / diagnosis
Chemical
Reg. No./Substance:
0/Chorionic Gonadotropin; 0/Epitopes; 0/Protein Isoforms; 0/Recombinant Proteins

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