Document Detail


The classical and alternate pathways of complement in oral contraceptive users.
MedLine Citation:
PMID:  3446439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Whole complement (CH50), C3, C4, the alternate pathway activity of complement (APH50) and factor B were measured in 159 women currently taking oral contraceptives and in 186 women who were not taking the pill. The mean levels of all components of the complement, except APH50, were found to be elevated in current users compared to non-users. The elevation in serum levels was seen in the first year after initiation of oral contraceptive use. Thereafter, levels changed little with duration of use. Among women who stopped using oral contraceptives, complement levels were similar to those of women who had never used the pill. Results appeared to be similar irrespective of the type of progestagen included in the oral contraceptive. These data provide support for the view that oral contraceptives have no adverse effect on the classical and the alternate pathways of complement.
Authors:
J M Delâge; G Lehner-Netsch; J Brisson
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Contraception     Volume:  36     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1988-05-26     Completed Date:  1988-05-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  627-32     Citation Subset:  IM    
Affiliation:
Centre d'hématologie et d'immunologie clinique, Hôpital du Saint-Sacrement, Québec, Canada.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Complement Activation / drug effects*
Complement C3 / analysis
Complement C4 / analysis
Complement Factor B / analysis
Complement Pathway, Alternative / drug effects*
Complement Pathway, Classical / drug effects*
Complement System Proteins / analysis
Contraceptives, Oral / pharmacology*
Female
Humans
Time Factors
Chemical
Reg. No./Substance:
0/Complement C3; 0/Complement C4; 0/Contraceptives, Oral; 9007-36-7/Complement System Proteins; EC 3.4.21.47/Complement Factor B

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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