Document Detail

On the classes of aminoacyl-tRNA synthetases, amino acids and the genetic code.
MedLine Citation:
PMID:  15279174     Owner:  NLM     Status:  MEDLINE    
The division of the aminoacyl-tRNA synthetases in two classes is compared with a division of the amino acids in two classes, obtained from the AAIndex databank by a principal component analysis. The division of the enzymes in Classes I and II follows to a great extent a division in the chemical and biological properties of their cognate amino acids. Furthermore, the phylogenetic trees of Classes I and II enzymes are highly correlated with dendrograms obtained for their cognate amino acids by using the indices in the AAIndex database. We argue that the evolution of aminoacyl-tRNA synthetases was determined by the characteristics of their corresponding amino acids. We interpret these results considering models for the origin and evolution of the genetic code in which an initial version, containing fewer amino acids, was modified by the incorporation of new amino acids following duplication and divergence of previous synthetases and tRNA molecules.
Andre R O Cavalcanti; Elisa Soares Leite; Benício B Neto; Ricardo Ferreira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life     Volume:  34     ISSN:  0169-6149     ISO Abbreviation:  Orig Life Evol Biosph     Publication Date:  2004 Aug 
Date Detail:
Created Date:  2004-07-28     Completed Date:  2005-02-02     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8610391     Medline TA:  Orig Life Evol Biosph     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  407-20     Citation Subset:  IM; S    
Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ, USA.
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MeSH Terms
Amino Acids / chemistry,  classification*
Amino Acyl-tRNA Synthetases / classification*
Databases as Topic
Evolution, Molecular
Genetic Code*
Reg. No./Substance:
0/Amino Acids; EC 6.1.1.-/Amino Acyl-tRNA Synthetases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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