| A class of plant glycosyltransferases involved in cellular homeostasis. | |
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MedLine Citation:
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PMID: 15241472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Many small lipophilic compounds in living cells can be modified by glycosylation. These processes can regulate the bioactivity of the compounds, their intracellular location and their metabolism. The glycosyltransferases involved in biotransformations of small molecules have been grouped into Family 1 of the 69 families that are classified on the basis of substrate recognition and sequence relatedness. In plants, these transfer reactions generally use UDP-glucose with acceptors that include hormones such as auxins and cytokinins, secondary metabolites such as flavonoids, and foreign compounds including herbicides and pesticides. In mammalian organisms, UDP-glucuronic acid is typically used in the transfer reactions to endogenous acceptors, such as steroid and thyroid hormones, bile acids and retinoids, and to xenobiotics, including nonsteroidal anti-inflammatory drugs and dietary metabolites. There is widespread interest in this class of enzyme since they are known to function both in the regulation of cellular homeostasis and in detoxification pathways. This review outlines current knowledge of these glycosyltransferases drawing on information gained from studies of plant and mammalian enzymes. |
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Authors:
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Eng-Kiat Lim; Dianna J Bowles |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2004-07-08 |
Journal Detail:
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Title: The EMBO journal Volume: 23 ISSN: 0261-4189 ISO Abbreviation: EMBO J. Publication Date: 2004 Aug |
Date Detail:
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Created Date: 2004-08-04 Completed Date: 2005-06-14 Revised Date: 2010-09-20 |
Medline Journal Info:
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Nlm Unique ID: 8208664 Medline TA: EMBO J Country: England |
Other Details:
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Languages: eng Pagination: 2915-22 Citation Subset: IM |
Affiliation:
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CNAP, Department of Biology, University of York, York, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Gene Expression Regulation, Plant Glycosylation Glycosyltransferases / chemistry, classification*, genetics, metabolism* Homeostasis* Plants / enzymology*, metabolism |
| Chemical | |
Reg. No./Substance:
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EC 2.4.-/Glycosyltransferases |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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