| cis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in rats. | |
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MedLine Citation:
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PMID: 12949384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study was designed to examine the effects of increasing dietary levels of vaccenic acid (VA) and cis-9, trans-11 conjugated linoleic acid (CLA) on chemically induced mammary carcinogenesis in rats. Both fatty acids were provided as a natural component in butter fat. The conversion of VA to CLA by delta9-desaturase was documented previously in several species, including rats and humans. Specifically, our objective was to determine the relative contribution of dietary VA and CLA to the tissue concentration of CLA and its ability to inhibit the development of mammary carcinomas. A total of 7 diets were formulated with varying levels of CLA and VA. The overall dietary treatment scheme was designed to evaluate the modulation of mammary cancer risk by 1). small increases of CLA in the presence of a low level of VA and 2). more substantial increases of VA against a background of low levels of CLA. As expected, small increases in dietary CLA at the low end of the CLA dose-response range did not reduce tumorigenesis. In contrast, there was a distinct and marked inhibitory response to VA that was dose dependent. The effect of VA was magnified in this experiment because the dose range of VA tested was much broader than that of CLA. Fatty acid analysis showed that the conversion of dietary VA to CLA resulted in a dose-dependent increase in the accumulation of CLA in the mammary fat pad, which was accompanied by a parallel decrease in tumor formation in the mammary gland. The finding confirms that the conversion of VA to CLA is as important for cancer prevention as the dietary supply of CLA. Thus, VA is also anticarcinogenic, and VA and CLA represent functional food components that are present in ruminant fat. |
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Authors:
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Benjamin A Corl; David M Barbano; Dale E Bauman; Clement Ip |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of nutrition Volume: 133 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-09-01 Completed Date: 2003-10-28 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 2893-900 Citation Subset: IM |
Affiliation:
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Department of Animal Science and. Department of Food Science, Cornell University, Ithaca, NY 14853, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Diet Dose-Response Relationship, Drug Fatty Acids / metabolism Female Linoleic Acids / administration & dosage* Lipids / blood Mammary Neoplasms, Experimental / etiology, prevention & control* Oleic Acids / administration & dosage Rats Rats, Sprague-Dawley Risk Assessment Stereoisomerism |
| Grant Support | |
ID/Acronym/Agency:
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CA16056/CA/NCI NIH HHS; CA61763/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acids; 0/Linoleic Acids; 0/Lipids; 0/Oleic Acids; 143-25-9/11-octadecenoic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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