Document Detail

cis-9, trans-11 CLA derived endogenously from trans-11 18:1 reduces cancer risk in rats.
MedLine Citation:
PMID:  12949384     Owner:  NLM     Status:  MEDLINE    
The present study was designed to examine the effects of increasing dietary levels of vaccenic acid (VA) and cis-9, trans-11 conjugated linoleic acid (CLA) on chemically induced mammary carcinogenesis in rats. Both fatty acids were provided as a natural component in butter fat. The conversion of VA to CLA by delta9-desaturase was documented previously in several species, including rats and humans. Specifically, our objective was to determine the relative contribution of dietary VA and CLA to the tissue concentration of CLA and its ability to inhibit the development of mammary carcinomas. A total of 7 diets were formulated with varying levels of CLA and VA. The overall dietary treatment scheme was designed to evaluate the modulation of mammary cancer risk by 1). small increases of CLA in the presence of a low level of VA and 2). more substantial increases of VA against a background of low levels of CLA. As expected, small increases in dietary CLA at the low end of the CLA dose-response range did not reduce tumorigenesis. In contrast, there was a distinct and marked inhibitory response to VA that was dose dependent. The effect of VA was magnified in this experiment because the dose range of VA tested was much broader than that of CLA. Fatty acid analysis showed that the conversion of dietary VA to CLA resulted in a dose-dependent increase in the accumulation of CLA in the mammary fat pad, which was accompanied by a parallel decrease in tumor formation in the mammary gland. The finding confirms that the conversion of VA to CLA is as important for cancer prevention as the dietary supply of CLA. Thus, VA is also anticarcinogenic, and VA and CLA represent functional food components that are present in ruminant fat.
Benjamin A Corl; David M Barbano; Dale E Bauman; Clement Ip
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of nutrition     Volume:  133     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-01     Completed Date:  2003-10-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2893-900     Citation Subset:  IM    
Department of Animal Science and. Department of Food Science, Cornell University, Ithaca, NY 14853, USA.
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MeSH Terms
Dose-Response Relationship, Drug
Fatty Acids / metabolism
Linoleic Acids / administration & dosage*
Lipids / blood
Mammary Neoplasms, Experimental / etiology,  prevention & control*
Oleic Acids / administration & dosage
Rats, Sprague-Dawley
Risk Assessment
Grant Support
Reg. No./Substance:
0/Fatty Acids; 0/Linoleic Acids; 0/Lipids; 0/Oleic Acids; 143-25-9/11-octadecenoic acid

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