| A circulating shock protein that depolarizes cells in vitro depresses myocardial contractility and rate in isolated rat hearts. | |
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MedLine Citation:
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PMID: 7966472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Previously, we identified the presence of a circulating shock protein (CSP) in the plasma of hemorrhaged rats that depolarizes a variety of cells in vitro. In isolated perfused rat hearts, partially purified CSP produced dose-dependent decreases in contractility and heart rate associated with an increase in coronary perfusion pressure (CPP). Electrical pacing failed to prevent the negative inotropic effects. Preventing the coronary vasoconstriction with nitroglycerin or attenuating it with a cyclooxygenase inhibitor also failed to prevent the inotropic or chronotropic effects of CSP. Carbocyclic thromboxane A2 (50ng/min) caused a similar increase in CPP to CSP but had no effect on contractility or rate during the first minute of infusion. These data indicate that the protein that appears in rat plasma after hemorrhage produces negative inotropic and chronotropic effects on the isolated heart that are independent of changes in CPP. Vasoactive arachidonic acid metabolites elicited by CSP are partially responsible for the increase in coronary vascular resistance. |
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Authors:
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R O Jones; D E Carlson; D S Gann |
Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The Journal of trauma Volume: 37 ISSN: 0022-5282 ISO Abbreviation: J Trauma Publication Date: 1994 Nov |
Date Detail:
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Created Date: 1994-12-29 Completed Date: 1994-12-29 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376373 Medline TA: J Trauma Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 752-8 Citation Subset: AIM; IM |
Affiliation:
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Department of Surgery, School of Medicine, University of Maryland, Baltimore. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Arrhythmia Agents / pharmacology Blood Proteins / pharmacology, physiology* Coronary Circulation / physiology Heart Rate / physiology* Male Myocardial Contraction / physiology* Nitroglycerin / pharmacology Rats Rats, Sprague-Dawley Salicylic Acid Salicylic Acids / pharmacology Thromboxane A2 / pharmacology |
| Grant Support | |
ID/Acronym/Agency:
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GM27946/GM/NIGMS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anti-Arrhythmia Agents; 0/Blood Proteins; 0/Salicylic Acids; 55-63-0/Nitroglycerin; 57576-52-0/Thromboxane A2; 69-72-7/Salicylic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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