| The circadian rhythm of tryptophan in breast milk affects the rhythms of 6-sulfatoxymelatonin and sleep in newborn. | |
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MedLine Citation:
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PMID: 16380706 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: The hormone melatonin regulates the sleep and this pineal hormone is synthesized in the organism from the amino acid tryptophan. It is known that breast-fed babies have better sleep patterns and a better entrained sleep/wake cycle than bottle-fed babies (adapted formula). OBJECTIVE: To compare the circadian rhythm of 6-sulfatoxymelatonin (aMT6s)--the metabolite of melatonin excreted in the urine--in urine of bottle-fed and breast-fed children, and relate it to the circadian rhythm of tryptophan in breast milk, also evaluating the possible effects on the baby's night-time rest. METHODS: 16 infants of 12 weeks of age were studied, divided into two groups depending on their exclusively natural or artificial feeding. The circadian rhythm of 6-sulfatoxymelatonin in urine was measured for the two groups of infants and for the breast-feeding mothers. In the breast milk, the circadian rhythm of the amino acid tryptophan was measured. The rest of the infants was tested by wrist actimeters for a week and the sleep parameters of the infants were measured and evaluated. RESULTS: The tryptophan in the breast milk presented a circadian rhythm with acrophase at around 03:00. This affected the 6-sulfatoxymelatonin circadian rhythm with acrophase at 06:00 in the breast-fed infants, and also promoted nocturnal sleep. Assumed sleep, actual sleep, and sleep efficiency were significantly increased in the breast fed infants with respect the formula fed infants. CONCLUSION: A temporal relationship was observed between the circadian rhythm of 6-sulfatoxymelatonin of the exclusively breast-fed babies and that of tryptophan in the mother's milk. Acting this amino acid as a zeitgeber entrainment of the biological rhythms in the breast-fed infant. |
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Authors:
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J Cubero; V Valero; J Sánchez; M Rivero; H Parvez; A B Rodríguez; C Barriga |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neuro endocrinology letters Volume: 26 ISSN: 0172-780X ISO Abbreviation: Neuro Endocrinol. Lett. Publication Date: 2005 Dec |
Date Detail:
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Created Date: 2006-03-16 Completed Date: 2006-06-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008373 Medline TA: Neuro Endocrinol Lett Country: Sweden |
Other Details:
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Languages: eng Pagination: 657-61 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Science, Extremadura University, Avda de Elvas s/n, 06071 Badajoz, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bottle Feeding Breast Feeding Circadian Rhythm / physiology* Female Humans Infant Infant, Newborn Male Melatonin / analogs & derivatives*, urine Milk, Human / metabolism* Reference Values Sleep / physiology* Statistics, Nonparametric Tryptophan / metabolism* |
| Chemical | |
Reg. No./Substance:
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2208-40-4/6-sulfatoxymelatonin; 73-22-3/Tryptophan; 73-31-4/Melatonin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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