| The circadian output gene takeout is regulated by Pdp1epsilon. | |
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MedLine Citation:
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PMID: 20133786 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The circadian clock controls many circadian outputs. Although a large number of transcripts are affected by the circadian oscillator, very little is known about their regulation and function. We show here that the Drosophila takeout gene, one of the output genes of the circadian oscillator, is regulated similarly to the circadian clock genes Clock (Clk) and cry. takeout RNA levels are at constant high levels in Clk(JRK) mutants. The circadian transcription factor PAR domain protein 1 (Pdp1epsilon) is a transcription factor that had previously been postulated to control clock output genes, particularly genes regulated similarly to Clk. In agreement with this, we show here that Pdp1epsilon is a regulator of takeout. Takeout levels are low in flies with reduced Pdp1epsilon and high in flies with increased amounts of Pdp1epsilon. Furthermore, flies with reduced or elevated Pdp1epsilon levels in the fat body display courtship defects, identifying Pdp1epsilon as an important transcriptional regulator in that tissue. |
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Authors:
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Juliana Benito; Valbona Hoxha; Chamala Lama; Anna A Lazareva; Jean-François Ferveur; Paul E Hardin; Brigitte Dauwalder |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. Date: 2010-01-21 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 107 ISSN: 1091-6490 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-02-10 Completed Date: 2010-05-07 Revised Date: 2012-05-29 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 2544-9 Citation Subset: IM |
Affiliation:
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Department of Biology and Biochemistry, University of Houston, Houston, TX 77204-5001, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Genetically Modified Basic-Leucine Zipper Transcription Factors / genetics*, metabolism Blotting, Northern Blotting, Western CLOCK Proteins / genetics, metabolism Circadian Rhythm / genetics* Courtship Drosophila Proteins / genetics*, metabolism Drosophila melanogaster / genetics*, metabolism, physiology Fat Body / metabolism Female Gene Expression Regulation Male Mutation Period Circadian Proteins / genetics, metabolism Reverse Transcriptase Polymerase Chain Reaction Sexual Behavior, Animal / physiology |
| Grant Support | |
ID/Acronym/Agency:
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R01 NS051280/NS/NINDS NIH HHS; R01 NS051280-08/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Basic-Leucine Zipper Transcription Factors; 0/Clk protein, Drosophila; 0/Drosophila Proteins; 0/PDP1 protein, Drosophila; 0/PER protein, Drosophila; 0/Period Circadian Proteins; 0/takeout protein, Drosophila; EC 2.3.1.48/CLOCK Proteins |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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