Document Detail

The circadian clock starts ticking at a developmentally early stage.
MedLine Citation:
PMID:  21135160     Owner:  NLM     Status:  In-Process    
Although overt diurnal rhythms of behavior do not begin until well after birth, molecular studies suggest that the circadian clock may begin much earlier at a cellular level: mouse embryonic fibroblasts, for example, already possess robust clocks. By multiple criteria, we found no circadian clock present in mouse embryonic stem cells. Nevertheless, upon their differentiation into neurons, circadian gene expression was observed. In the first steps along the pathway from ES cells to neurons, a neural precursor cell (NPC) line already showed robust circadian oscillations. Therefore, at a cellular level, the circadian clock likely begins at the very earliest stages of mammalian development.
Elzbieta Kowalska; Ermanno Moriggi; Christoph Bauer; Charna Dibner; Steven A Brown
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biological rhythms     Volume:  25     ISSN:  1552-4531     ISO Abbreviation:  J. Biol. Rhythms     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-07     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8700115     Medline TA:  J Biol Rhythms     Country:  United States    
Other Details:
Languages:  eng     Pagination:  442-9     Citation Subset:  IM    
Institute of Pharmacology and Toxicology, University of Zurich, Zurich, Switzerland.
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