Document Detail


The ciliary membrane.
MedLine Citation:
PMID:  20399632     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cilia and flagella are important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models of ciliary membrane biogenesis, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.
Authors:
Rajat Rohatgi; William J Snell
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-04-17
Journal Detail:
Title:  Current opinion in cell biology     Volume:  22     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-26     Completed Date:  2010-10-28     Revised Date:  2014-09-09    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cilia / metabolism*
Humans
Intracellular Membranes / metabolism*
Lipid Metabolism
Membrane Proteins / metabolism
Protein Transport
Signal Transduction
Grant Support
ID/Acronym/Agency:
GM 25661/GM/NIGMS NIH HHS; R00 CA129174/CA/NCI NIH HHS; R00 CA129174/CA/NCI NIH HHS; R00 CA129174-03/CA/NCI NIH HHS; R01 GM025661/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Membrane Proteins
Comments/Corrections

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