| Is chronic synovitis an example of reperfusion injury? | |
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MedLine Citation:
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PMID: 3755583 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In an attempt to define why the joint synovial cavity is prone to develop persistent synovial inflammation we show that hypoxia is induced by pressure changes caused by exercise in the presence of an inflammatory effusion. On resting 'reperfusion injury' may take place. The biochemistry of reperfusion injury has only recently been defined and perhaps surprisingly for an insult that has hypoxia as its central ingredient involves the subsequent production of oxygen derived free radical species. We apply the reaction sequences that are believed to occur during hypoxic/reperfusion injury to the joint synovial cavity and, on the basis of reported 'in vivo' observations, suggest novel therapeutic approaches that we believe are applicable to the treatment of persistent synovial inflammation. |
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Authors:
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T Woodruff; D R Blake; J Freeman; F J Andrews; P Salt; J Lunec |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 45 ISSN: 0003-4967 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 1986 Jul |
Date Detail:
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Created Date: 1986-09-17 Completed Date: 1986-09-17 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 608-11 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anoxia / complications Cats Chronic Disease Free Radicals Humans Ischemia / etiology Knee Joint / physiopathology Oxygen / metabolism Partial Pressure Perfusion Physical Exertion Rats Synovitis / physiopathology* Xanthine Oxidase / metabolism Xanthines / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Free Radicals; 0/Xanthines; 7782-44-7/Oxygen; EC 1.17.3.2/Xanthine Oxidase |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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