| The chronic effect of nitrendipine on heart and regional blood flow in renovascular hypertensive rats. | |
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MedLine Citation:
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PMID: 2961897 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Nitrendipine, a new calcium entry blocker, was administered to renovascular hypertensive rats (2K1C Goldblatt) (RHR, n = 8) and sham operated control rats (ShC, n = 8) to evaluate the effects on left ventricular hypertrophy and regional blood flow using radioactive microspheres. Nine untreated RHR and 8 untreated ShC served as control groups. After 6 weeks treatment (20 mg/kg subcutaneously, every other day), blood pressure reduced significantly in both RHR and ShC associated with a reduction in total peripheral resistance. Significant reversal of left ventricular hypertrophy was noted in RHR (1278 +/- 41 to 1024 +/- 19 mg, p less than 0.01), but not in ShC. There was a significant relationship between blood pressure and left ventricular mass in both untreated rats (r = 0.955, p less than 0.001) and treated rats (r = 0.729, p less than 0.005). Nitrendipine increased coronary blood flow in RHR (430 +/- 30 to 566 +/- 47 ml/m/100g, p less than 0.05) as well as in ShC (375 +/- 15 to 508 +/- 29 ml/ml/100g, p less than 0.05), without increasing cardiac oxygen demand. Renal blood flow was unchanged, whereas cerebral blood flow was significantly increased in both RHR (128 +/- 6 to 164 +/- 13 ml/m/100g, p less than 0.01) and ShC (124 +/- 7 to 173 +/- 5 ml/m/100g, p less than 0.01). Thus, long treatment of nitrendipine effectively regressed cardiac hypertrophy toward normal. Nitrendipine reduced total peripheral resistance; however, the effects on regional blood flow were not uniform among various organs. |
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Authors:
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K Kobayashi; R C Tarazi |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Japanese circulation journal Volume: 51 ISSN: 0047-1828 ISO Abbreviation: Jpn. Circ. J. Publication Date: 1987 Sep |
Date Detail:
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Created Date: 1988-02-04 Completed Date: 1988-02-04 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7806868 Medline TA: Jpn Circ J Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1027-34 Citation Subset: IM |
Affiliation:
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Second Department of Internal Medicine, Yokohama University School of Medicine, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Pressure / drug effects Cardiac Output / drug effects Cardiomegaly / drug therapy Cerebrovascular Circulation / drug effects* Coronary Circulation / drug effects* Hypertension, Renovascular / drug therapy Male Nitrendipine / pharmacology*, therapeutic use Rats Rats, Inbred Strains Renal Circulation / drug effects* |
| Chemical | |
Reg. No./Substance:
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39562-70-4/Nitrendipine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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