Document Detail

On the chromatin structure of eukaryotic telomeres.
MedLine Citation:
PMID:  21822057     Owner:  NLM     Status:  MEDLINE    
Telomeres prevent chromosome fusions and degradation by exonucleases and are implicated in DNA repair, homologous recombination, chromosome pairing and segregation. All these functions of telomeres require the integrity of their chromatin structure, which has been traditionally considered as heterochromatic. In agreement with this idea, different studies have reported that telomeres associate with heterochromatic marks. However, these studies addressed simultaneously the chromatin structures of telomeres and subtelomeric regions or the chromatin structure of telomeres and Interstitial Telomeric Sequences (ITSs). The independent analysis of Arabidopsis telomeres, subtelomeric regions and ITSs has allowed the discovery of euchromatic telomeres. In Arabidopsis, whereas subtelomeric regions and ITSs associate with heterochromatic marks, telomeres exhibit euchromatic features. We think that this scenario could be found in other model systems if the chromatin organizations of telomeres, subtelomeric regions and ITSs are independently analyzed.
María I Vaquero-Sedas; Miguel A Vega-Palas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-01
Journal Detail:
Title:  Epigenetics : official journal of the DNA Methylation Society     Volume:  6     ISSN:  1559-2308     ISO Abbreviation:  Epigenetics     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2012-06-08     Completed Date:  2012-10-02     Revised Date:  2013-06-28    
Medline Journal Info:
Nlm Unique ID:  101265293     Medline TA:  Epigenetics     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1055-8     Citation Subset:  IM    
Instituto de Bioquímica Vegetal y Fotosíntesis, Universidad de Sevilla-CSIC, Seville, Spain.
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MeSH Terms
Arabidopsis / chemistry,  genetics*
Base Sequence
Chromatin / chemistry*,  genetics
Chromatin Assembly and Disassembly
Chromatin Immunoprecipitation / methods
Chromosome Aberrations
Chromosomes / chemistry,  genetics
Telomere / chemistry*,  genetics
Reg. No./Substance:

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